Macular degeneration trials in United States

In United States 96 Also abroad 218

96 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Cell Collection to Study Eye Diseases
Where
Bethesda
Age
1 day to 120 years
People
930
Run by
National Eye Institute (NEI)
See details and how to joinNCT01432847
Phase 2Taking people
A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD
Where
Beverly Hills, Hagerstown, Walnut Creek
Age
55 years to 64 years
People
110 worldwide
Run by
Galimedix Therapeutics Inc
See details and how to joinNCT06659549 · EU 2024-519128-26-00
Phase 2Taking people
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Where
Bellaire, Boston, Boynton Beach, Deerfield Beach, Erie, Houston, Huntington Beach, Katy, Metairie, New York, Philadelphia, Sacramento, Santa Barbara, St. Petersburg, Toms River
Age
50 years and over
People
272 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07441642 · EU 2025-523704-77-00
No phaseTaking people
Pivotal Trial of an Automated AI-based System for Early Diagnosis and Prediction of Late Age-related Macular Degeneration
Where
Richmond Hill
Age
50 years and over
People
1,076
Run by
iHealthScreen Inc
See details and how to joinNCT07084883
Phase 1/2Taking people
Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration
Where
Baltimore, Bethesda
Age
55 years to 95 years
People
20
Run by
National Eye Institute (NEI)
See details and how to joinNCT04339764
Phase 3Taking people
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Where
Abilene, Albuquerque, Asheville, Augusta, Aurora, Austin, Baltimore, Bellaire, Bethlehem, Beverly Hills, Bonita Springs, Boston, Brentwood, Bristol, Burlington, Carmel, Cary, Chandler, Cherry Hill, Chevy Chase, Chicago, Cincinnati, Cleveland, Colorado Springs, Columbus, Coral Springs, Dallas, Denver, Dublin, Durango, Edmond, Encino, Erie, Eugene, Fairfax, Fort Lauderdale, Fort Myers, Fort Worth, Fresno, Fullerton, Grand Blanc, Greenville, Hagerstown, Hickory, Hudson, Huntington Beach, Irvine, Jacksonville, Katy, Ladson, La Jolla, Lakeland, Lakewood, Lemont, Lenexa, Liverpool, Long Beach, Longmont, Los Angeles, Louisville, Lynchburg, Madison, Manchester, Marietta, McAllen, Metairie, Modesto, Morgantown, Mountain View, Mt. Pleasant, Naples, Nashua, Nashville, New Orleans, New York, Oak Park, Orlando, Oxnard, Palm Beach Gardens, Palm Desert, Pasadena, Philadelphia, Phoenix, Pinellas Park, Plano, Portland, Poughkeepsie, Poway, Rapid City, Redlands, Richmond, Riverside, Round Rock, Rowland Heights, Sacramento, Salt Lake City, San Antonio, San Francisco, Santa Ana, Sarasota, Scottsdale, Sewickley, Sioux Falls, Southaven, Southlake, Spokane, Springdale, Springfield, St Louis, St. Petersburg, Tampa, Teaneck, The Woodlands, Toms River, Torrance, Tucson, Tulsa, Tyler, Wake Forest, Waltham, Waterford, West Columbia, West Jordan, West Monroe, Winston-Salem, Winter Haven, Worcester
Age
50 years to 85 years
People
975 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06541704 · EU 2023-509547-27-00
Phase 2Taking people
Safety and Efficacy of AIV007 Periocular Injection in Patients With Neovascular Age-Related Macular Degeneration
Where
McAllen, Torrance
Age
50 years to 85 years
People
35
Run by
AiViva BioPharma, Inc.
See details and how to joinNCT07557121
Phase 2/3Taking people
A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)
Where
Asheville, Austin, Baltimore, Beaufort, Boston, Carmel, Chevy Chase, Cincinnati, Cleveland, Dallas, Durham, Erie, Eugene, Fort Lauderdale, Fullerton, Gainesville, Grand Rapids, Hagerstown, Hickory, La Jolla, Lemont, Liverpool, Lynchburg, Marietta, Norfolk, Oxnard, Pasadena, Pensacola, Portland, Poway, Reno, Saint Louis Park, Salt Lake City, San Antonio, Spokane, Springfield, St Louis, St. Petersburg, The Woodlands, Tucson, Wake Forest, Walnut Creek, Willow Park
Age
60 years and over
People
274 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06635148 · EU 2022-500747-21-00
Phase 1Taking people
Phase 1 Study of C.001 in Retinal Degeneration
Where
Beverly Hills, Palo Alto, Sacramento
Age
18 years and over
People
15
Run by
Cellio Therapeutics Inc
See details and how to joinNCT07594236
No phaseTaking people
Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)
Where
Atlanta, Dallas, Erie, Fargo, Madison, McAllen, Salt Lake City, The Woodlands
Age
50 years and over
People
1,000 worldwide
Run by
University of Wisconsin, Madison
See details and how to joinNCT06924021
Phase 3Taking people
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Where
Abilene, Augusta, Austin, Baltimore, Bluffton, Burleson, Campbell, Carmel, Charleston, Cleveland, Colorado Springs, Columbus, Deerfield Beach, Delray Beach, Dublin, Edina, Encino, Erie, Fort Myers, Houston, Huntington Beach, Ladson, La Jolla, Lakewood, Lenexa, Little Silver, Longmont, Mesa, Mountain View, Mt. Pleasant, Murray, Newport Beach, Oak Lawn, Orlando, Philadelphia, Portland, Poway, Rapid City, Redlands, Reno, Riverside, Rochester, Round Rock, Royal Oak, Sacramento, San Antonio, San Francisco, Santa Ana, Springfield, St Louis, Sun City, Towson, West Des Moines, Winter Haven
Age
50 years and over
People
561 worldwide
Run by
AbbVie
See details and how to joinNCT07007065 · EU 2024-512298-28-00
No phaseNot yet taking people in United States
Remapping Text in Sentence and Word Tasks to Aid Reading With Central Vision Loss
Where
Edina
Age
16 years and over
People
216
Run by
University of Minnesota
See details and how to joinNCT07216924
Phase 3Taking people
Extension Study for the Port Delivery System With Ranibizumab (Portal)
Where
Albuquerque, Arlington, Augusta, Austin, Bakersfield, Baltimore, Bellaire, Beverly Hills, Bloomfield, Boston, Boynton Beach, Charlotte, Chesterfield, Chevy Chase, Cincinnati, Cleveland, Columbus, Durango, Edmond, Encino, Florence, Fort Collins, Fort Myers, Fort Worth, Germantown, Grand Rapids, Great Neck, Joliet, La Jolla, Lakewood, Lenexa, Lexington, Los Angeles, Marietta, Melbourne, Minneapolis, Mountain View, Nashville, Oak Forest, Paducah, Palm Beach Gardens, Pensacola, Philadelphia, Phoenix, Plantation, Portland, Poway, Reno, Rochester, Rockville Centre, Royal Oak, Sacramento, Salt Lake City, San Antonio, San Francisco, Santa Ana, Santa Barbara, Silverdale, Spokane, St Louis, St. Petersburg, Syracuse, Tallahassee, Tampa, Teaneck, The Woodlands, Towson, Virginia Beach, Waterford, West Columbia, West Des Moines
Age
50 years and over
People
1,000 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT03683251 · EU 2023-507131-38-00
No phaseTaking people
National Eye Institute Biorepository for Retinal Diseases
Where
Bethesda
Age
2 years to 120 years
People
650
Run by
National Eye Institute (NEI)
See details and how to joinNCT01496625
No phaseEnrolling by invitation
Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) Sub-study
Where
Madison
Age
50 years and over
People
10
Run by
University of Wisconsin, Madison
See details and how to joinNCT07747662
Phase 2Taking people
A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Where
Arlington, Erie, Lynchburg, Walnut Creek, Winston-Salem
Age
50 years and over
People
321
Run by
Genentech, Inc.
See details and how to joinNCT07851259 · EU 2026-527027-10-00
Phase 4Not yet taking people in United States
Iopidine to Decrease Intraocular Pressure Rise After Injections
Where
Easton
Age
18 years and over
People
120
Run by
Retina Consultants of Delmarva
See details and how to joinNCT07891910
Phase 2Taking people
A Dose-masked Study of Intravitreal Remigromig (EYE103) in Participants With NVAMD or Macular Edema Following BRVO
Where
Abilene, Amarillo, Asheville, Austin, Bellaire, Bloomfield, Burleson, Cary, Charleston, Dallas, Denver, Fort Lauderdale, Germantown, Glendale, Great Neck, Greenville, Hagerstown, Jacksonville, Knoxville, Lemont, Madison, Modesto, Mountain View, Nashville, Orlando, Plano, Round Rock, Sacramento, San Antonio, San Marcos, Santa Ana, Scottsdale, The Woodlands, Wake Forest, West Columbia, West Jordan, Willow Park
Age
18 years and over
People
160
Run by
EyeBiotech Ltd.
See details and how to joinNCT07205887
Phase 1/2Taking people
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Where
Arlington, Augusta, Austin, Bellaire, Bethlehem, Beverly Hills, Chevy Chase, Dallas, Encino, Erie, Eugene, Gainesville, Hagerstown, Ladson, Lemont, Oxnard, Peoria, Reno, Sacramento, San Antonio, Scottsdale, Southlake, St. Petersburg, Stuart, Torrance, Towson, Wake Forest, Walnut Creek
Age
60 years and over
People
104 worldwide
Run by
Sanofi
See details and how to joinNCT07215234
Phase 3Taking people
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Where
Amarillo, Austin, Baltimore, Bloomfield, Bluffton, Campbell, Carmel, Cary, Cincinnati, Colorado Springs, Dallas, Denver, Durango, Elmhurst, Erie, Eugene, Fullerton, Grand Rapids, Hagerstown, Hudson, Johnson City, Lakeland, Liverpool, Lynchburg, Mountain View, Mt. Pleasant, Nashville, New York, Oak Forest, Oak Park, Orlando, Pensacola, Portland, Rapid City, Reno, Sacramento, Salt Lake City, Sandy Springs, San Francisco, San Marcos, Scottsdale, Silverdale, Springfield, St Louis, St. Petersburg, Stuart, Sun City, Tampa, Tucson, Tyler, Wake Forest, Walnut Creek, Wausau, Westbury, West Columbia, West Monroe, Willow Park
Age
50 years and over
People
480 worldwide
Run by
4D Molecular Therapeutics
See details and how to joinNCT07064759
Phase 1Taking people
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
Where
Naples
People
20 worldwide
Run by
The Foundation for Orthopaedics and Regenerative Medicine
See details and how to joinNCT05147701
No phaseTaking people
A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)
Where
Bethlehem, Carmel, Dallas, Durham, La Crosse, Mountain View, Oak Forest, Reno, Springfield, Wake Forest
Age
55 years and over
People
75 worldwide
Run by
Complement Therapeutics
See details and how to joinNCT07144137
Phase 1/2Taking people
An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)
Where
Carmel, Dallas, La Crosse, Reno
Age
55 years and over
People
75 worldwide
Run by
Complement Therapeutics
See details and how to joinNCT07392255
Phase 2Taking people
A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251
Where
Austin, Baltimore, Bellaire, Beverly Hills, Blue Ash, Durham, Lynchburg, Nashville, Philadelphia, Reno, Sacramento, San Francisco, Spokane, St Louis, St. Petersburg
Age
50 years and over
People
60 worldwide
Run by
Genentech, Inc.
See details and how to joinNCT05626114
Phase 3Taking people
A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration
Where
Albuquerque, Arlington, Austin, Baltimore, Beaufort, Bellaire, Bellevue, Bloomfield, Boston, Carmel, Charleston, Chicago, Colorado Springs, Columbia, Dallas, Dublin, Edina, Elmhurst, Falls Church, Fort Worth, Fullerton, Hagerstown, Houston, Katy, Kingston, Ladson, Lakewood, Liverpool, Long Beach, Madison, Miami, Modesto, Mt. Pleasant, Naples, Nashville, Oceanside, Pasadena, Pensacola, Raleigh, Sacramento, Salt Lake City, San Antonio, Santa Barbara, Scarsdale, Schertz, Silverdale, Spokane, St Louis, Towson, Wake Forest, Waterford, West Columbia, Willow Park
Age
50 years and over
People
304 worldwide
Run by
Amgen
See details and how to joinNCT07614776 · EU 2025-523500-72-00