Stool test versus colonoscopy to check for advanced bowel growths
Studies a stool test in adults with past colon polyps or family history.
Key facts
- Who runs it
- University of Calgary
- Where
- Calgary, CanadaSee the site
- Trial code
- Registry title
- Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy
- Status
- Recruiting
- People taking part
- 3,000 people, planned
- Started
- 15 Apr 2022
- Expected to end
- 15 Apr 2027
- Type of study
- Observational
- Record updated
- 31 May 2022
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults up to 74 years old who have had polyps in the colon or rectum, or who have a family history of bowel cancer or polyps. It will see how well a stool test (FIT) works compared with colonoscopy.
- Age
- 18 to 74 years
- Sex
- Men and women
- Disease stage
- Personal history of low risk polyps, personal history of high risk polyps, or family history of colorectal cancer or polyps.
- Earlier treatment
- No colonoscopy within the previous 30 months.
Main reasons for not taking part
- Known acromegaly, cystic fibrosis or a high risk profession (firefighter)
- Sent for colonoscopy because of a positive fecal immunochemical test or CT colonography
- Known or suspected carrier of a gene for a familial cancer syndrome
- Does not meet the medical criteria for colonoscopy at the CCSC
- Cannot give written consent or fill in questionnaires
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Men or women age ≤ 74 years of age
- At least one risk factor for CRC that would generally lead to colonoscopy screening:; Personal history of low risk polyps; Personal history of high risk polyps; Family history of CRC or polyps
Who cannot take part
- Colonoscopy within the previous 30 months
- Known or suspected gene carrier for a familial cancer syndrome
- Known acromegaly, cystic fibrosis or high risk profession (firefighter)
- Referred for colonoscopy due to a positive fecal immunochemical test or CT colonography
- Does not meet medical criteria for colonoscopy at the CCSC
- Unable to provide written informed consent or complete questionnaires due to language barrier or other reasons
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 74 years old?
Where in Canada
- Forzani & Macphail Colon Cancer Screening Centre, University of CalgaryCalgary, CanadaContact: Robert HilsdenTaking people
About the trial
What the trial wants to find out
This is an observational study in a clinical setting to estimate the prevalence of advanced colorectal neoplasia (ACN) at colonoscopy in those with a history of low or high risk polyps or a family history of CRC/polyps and to verify the test performance characteristics of FIT in these populations. Using this information, a risk prediction model will be developed to help guide the choice between FIT and colonoscopy in the ongoing surveillance or screening of patients.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy (FIT2RUN Study)
- Plain-language title
- Stool test versus colonoscopy to check for advanced bowel growthsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05396560, who can take part
- Record updated
- 31 May 2022