Colorectal cancer trials in Canada

In Canada 89 Also abroad 1929

89 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Where
Montreal, Toronto
Age
18 years and over
People
542 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT04929223 · EU 2023-505163-37-00
Phase 1Taking people
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
Where
Toronto
Age
18 years to 99 years
People
600 worldwide
Run by
Erasca, Inc.
See details and how to joinNCT06983743 · EU 2026-525794-39-00
Phase 2Not yet taking people in Canada
Alberta Cancer Exercise Dose in Colorectal Cancer
Where
Calgary
Age
18 years and over
People
90
Run by
University of Calgary
See details and how to joinNCT07913906
Phase 3Taking people
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Where
Brampton, Montreal, Regina, Toronto, Vancouver
Age
18 years and over
People
900 worldwide
Run by
Summit Therapeutics
See details and how to joinNCT07228832
Phase 3Taking people
A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
Where
Ottawa, Toronto, Vancouver
Age
18 years and over
People
1,020 worldwide
Run by
EMD Serono Research & Development Institute, Inc.
See details and how to joinNCT07549412 · EU 2025-524648-37-00
Phase 2/3Taking people
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Where
Barrie, Calgary, Cambridge, Greenfield Park, Hamilton, Kingston, Kitchener, Lévis, London, Markham, Montreal, Newmarket, Oshawa, Ottawa, Prince George, Québec, Regina, Saint Catharines, Saint John, Saskatoon, Sherbrooke, St. John's, Toronto, Vancouver, Victoria, Windsor
Age
18 years and over
People
1,912 worldwide
Run by
NRG Oncology
See details and how to joinNCT05174169
Phase 2Taking people
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Where
Halifax, Montreal, Toronto
Age
18 years and over
People
111 worldwide
Run by
Bayer
See details and how to joinNCT06760819 · EU 2024-517419-62-00
Phase 3Taking people
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Where
Chicoutimi, London, Moncton, Montreal, Toronto, Winnipeg
Age
18 years and over
People
477 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06997497 · EU 2024-517232-22-00
Phase 1Taking people
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Where
Hamilton, Montreal, Toronto
Age
18 years and over
People
421 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07114601 · EU 2025-522367-15-00
Phase 1/2Taking people
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Where
Ottawa, Toronto, Vancouver
Age
18 years and over
People
225 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05379595 · EU 2023-506517-22-00
Phase 2Taking people
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
Where
Calgary
Age
18 years and over
People
146 worldwide
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT05673148
Phase 3Taking people
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Where
Calgary, Montreal, Ottawa, Toronto
Age
18 years and over
People
1,000 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06662786 · EU 2024-513852-13-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Where
Edmonton, Greenfield Park, Hamilton, Lévis, Saint-Jérôme, Saskatoon, Toronto
Age
18 years and over
People
700 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07284849 · EU 2025-523735-19-00
No phaseTaking people
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
Where
Toronto
Age
18 years and over
People
180
Run by
Unity Health Toronto
See details and how to joinNCT07387263
Phase 1/2Taking people
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Where
Montreal, Ottawa
Age
18 years and over
People
220 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06428409 · EU 2023-508703-21-00
Phase 2Not yet taking people in Canada
Adaptive Radiotherapy for Safe Hypofractionation
Where
Montreal
People
264
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT07516210
Phase 1/2Taking people
BOLD-100 in Combination With FOLFOX With or Without Bevacizumab for the Treatment of Advanced, Solid Tumours
Where
Edmonton, Hamilton, Montreal, Ottawa, Toronto
Age
18 years and over
People
220 worldwide
Run by
Bold Therapeutics, Inc.
See details and how to joinNCT04421820 · EU 2024-517500-11-00
Phase 2Taking people
SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases
Where
Edmonton
Age
18 years and over
People
24
Run by
AHS Cancer Control Alberta
See details and how to joinNCT05775146
No phaseTaking people
Protein Needs Study
Where
Edmonton
Age
45 years to 80 years
People
40
Run by
University of Alberta
See details and how to joinNCT04144907
Phase 2Taking people
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
Where
Calgary, Edmonton, London, Montreal, Toronto
Age
18 years and over
People
390 worldwide
Run by
AbbVie
See details and how to joinNCT06820463 · EU 2024-512981-33-00
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Where
Calgary, Halifax, Montreal, Ottawa, Sherbrooke, Toronto
Age
18 years and over
People
990 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07221357 · EU 2025-523224-45-00
Phase 1Taking people
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Where
Toronto, Vancouver
Age
18 years and over
People
280 worldwide
Run by
Vividion Therapeutics, Inc.
See details and how to joinNCT06004245 · EU 2023-503170-20-01
Phase 1/2Taking people
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Where
Calgary, Montreal, Sherbrooke, Toronto
Age
18 years and over
People
346 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06885034
Phase 1Taking people
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Where
Montreal
Age
18 years and over
People
180 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07261631
Phase 3Taking people
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Where
Montreal, Toronto
Age
18 years and over
People
800 worldwide
Run by
Pfizer
See details and how to joinNCT07222800 · EU 2025-523521-18-00