Early access
Sign in
Enrolling by invitationNo phase

Studying how the gut absorbs sugar to predict weight loss after surgery

Studies gut sugar absorption in adults with obesity considering bariatric surgery.

Key facts

Who runs it
Mayo Clinic
Where
Jacksonville, United StatesSee the site
Trial code
Registry title
Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome
Status
Enrolling by invitation
People taking part
52 people, planned
Started
1 Jul 2026
Expected to end
Aug 2028
Type of study
Observational, 2 groups
Treatments tested
  • Endoscopic biopsy
Record updated
2 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with obesity who are scheduled for weight loss surgery, and lean adults who have not had this surgery. All of them have a routine endoscopy.

Age
18 years or older
Sex
All sexes can join
Disease stage
Obesity with BMI 30 or higher and weight loss surgery planned, or lean with BMI 25 or lower and no weight loss surgery before
Earlier treatment
No past surgery on the stomach or small intestine. No weight loss medicines in use.

Main reasons for not taking part

  • Pregnant women
  • Adults who cannot give consent, including non-English speakers
  • Prisoners
  • Type 1 diabetes
  • Cancer that was active within the last 5 years

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Obese patients (BMI ≥ 30) scheduled for BS undergoing standard of care screening EGD, or lean BS-naïve individuals (BMI ≤ 25) subjected to EGD for routine clinical indications as part of standard care

Who cannot take part

  • Pregnant women because endoscopy is a risk factor. All patients of childbearing age undergo history as well as urine pregnancy test as a standard of care prior to undergoing endoscopy as the procedure is performed under anesthesia
  • Using weight loss medications
  • Subjects with preexisting conditions (e.g., bleeding at the time of the procedure, suspected perforation during the standard-of-care procedure) will be excluded from the study at the time of the endoscopy
  • A history of surgery on the stomach or small intestine
  • Type 1 diabetes (clinical diagnosis and/or positive glutamic acid decarboxylase antibodies)
  • Active malignancy within the last 5 years
  • Adults unable to consent, including non-English speakers
  • Prisoners
  • Have a contraindication to endoscopy

Where in United States

  • Mayo Clinic FloridaJacksonville, United StatesEnrolling by invitation

About the trial

What the trial wants to find out

This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.

The 2 groups in the trial

  • Obese patients scheduled for Bariatric surgery

    Subjects scheduled for Bariatric Surgery (BS) and will receive pre-BS Esophagogastroduodenoscopy (EGD) as a part of your standard care will have biopsies from the small intestine taken during the EGD procedure for this study.

    Treatment: Endoscopic biopsy

  • Lean controls naive to Bariatric surgery

    Subjects presenting for surveillance/screening EGD procedure as part of their standard medical care will have biopsies from the small intestine taken during the EGD procedure for this study.

    Treatment: Endoscopic biopsy

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Dietary Sugar Hyper-absorptive Intestinal Phenotype as a Predictor of Weight Loss Post-bariatric Surgery
Plain-language title
Studying how the gut absorbs sugar to predict weight loss after surgeryGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
2 October 2026