PRP in ACLR to Prevent PTOA
Key facts
- Who runs it
- Hospital for Special Surgery, New York
- Where
- New York, United StatesSee the site
- Trial code
- Status
- Recruiting
- Phase
- Phase 3
- People taking part
- 56 people, planned
- Started
- 27 Jun 2022
- Expected to end
- 31 Dec 2026
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- platelet rich plasma (PRP) injection
- placebo saline injection
- Record updated
- 13 February 2026
Who can take part
- Age
- 14 years to 50 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Acute ACL injury within 6 weeks of presentation
- Age 14-50
- Male or female
- Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)
Who cannot take part
- Prior ACL reconstruction
- Prior cartilage repair procedure
- Prior meniscus surgery within 12 months
- Prior steroid, hyaluronic acid, or PRP injection within 6 months
- History of inflammatory arthritis or joint sepsis
- Other ligament injury requiring repair
- Any cartilage lesion requiring repair
- Any cartilage lesion greater than grade 2 (partial thickness injury)
- Non English speakers
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 14 and 50 years old?
Where in United States
- Hospital for Special SurgeryNew York, United StatesContact: Jessica Andres-Bergos, PhDTaking people
About the trial
What the trial wants to find out
The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.
The 2 groups in the trial
- Control ArmPlacebo, for comparison
The control arm will receive a pre-op placebo injection of saline, and ACLR surgery with intra-op placebo injection
Treatment: placebo saline injection
- Investigational ArmTreatment being tested
The investigational arm will receive a pre-op PRP injection, and ACLR surgery with PRP injection
Treatment: platelet rich plasma (PRP) injection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial
- Fit questions
- Built from NCT05412381, who can take part
- Record updated
- 13 February 2026