Following youth with bipolar disorder over 12 months to track their course
Follows children and teens aged 9 to 19 with bipolar spectrum disorders over one year.
Plain-language title generated from the registry record
Registry title: Children's Bipolar Network Treatment Trial I
Key facts
- Where
- Aurora, Los Angeles, Pittsburgh, and Richmond, United StatesSee the 4 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 9 and 19 years old?
Source: NCT05427123, who can take part
Where in United States
- University of Colorado Anschutz Medical Campus, Helen and Arthur E. Johnson Depression CenterAurora, United StatesEnrolling by invitation
- University of California, Los Angeles, Max Gray Child and Adolescent Mood Disorders Program (CHAMP)Los Angeles, United StatesTaking people
- University of Pittsburgh Child and Adolescent Bipolar Spectrum Services Clinic (CABS)Pittsburgh, United StatesEnrolling by invitation
- Virginia Commonwealth University Medical CenterRichmond, United StatesEnrolling by invitation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, Los Angeles
- Trial code
- NCT05427123
- Record updated
- 5 February 2026
- Original description
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of this study are to (1) identify and reliably diagnose youth (ages 9 to 19 yrs) with full bipolar disorder (BD) and BSDs, and (2) examine predictors (e.g., mood instability, inflammatory marker C-reactive protein) of clinical outcome over a 12 month period. Participating youth will initially complete a screening that includes a structured diagnostic interview and a baseline blood draw to measure inflammatory processes. Youth with BSD and parents (80 families) will be asked to participate in multiple follow up research visits with interviews, rating instruments, and questionnaires. Per established CBN guidelines, study psychiatrists will provide and track medication management and sites will also track psychosocial treatments. This study ultimately aims to further understanding of best practice pediatric BSD psychiatric and psychosocial treatments and development of a standardized and validated set of clinical tools for patient assessment, diagnosis, and tracking.Read full original descriptionShow less
A Collaborative Treatment Network for Youth With or at High Risk for Bipolar Disorder
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN). CBN sites have expertise in diagnosing, assessing, and treating BSDs in youth. The primary aims of this study are to (1) identify and reliably diagnose youth (ages 9 to 19 yrs) with full bipolar disorder (BD) and BSDs, and (2) examine predictors (e.g., mood instability, inflammatory marker C-reactive protein) of clinical outcome over a 12 month period. Participating youth will initially complete a screening that includes a structured diagnostic interview and a baseline blood draw to measure inflammatory processes. Youth with BSD and parents (80 families) will be asked to participate in multiple follow up research visits with interviews, rating instruments, and questionnaires. Per established CBN guidelines, study psychiatrists will provide and track medication management and sites will also track psychosocial treatments. This study ultimately aims to further understanding of best practice pediatric BSD psychiatric and psychosocial treatments and development of a standardized and validated set of clinical tools for patient assessment, diagnosis, and tracking.
Inclusion: Youth 9-19 years old; Youth diagnosed with Bipolar disorder (I, II, Other Specified) or Cyclothymic Disorder by the study team during the diagnostic interview screening; Youth is able to read and communicate in English to the degree necessary to be able to assent and participate (with help) in their treatment and assessments appropriate for ages 9 and up; Youth has a caregiver able to participate in ongoing basis in assessment and treatment; The participating caregiver can reliably read and communicate in English for purposes of study consenting, assessment, and treatment, unless preferred language translation services are regularly available.
Exclusion: Youth has DSM-5 diagnosis of autism spectrum disorder; Youth has DSM-5 diagnosis of substance or alcohol abuse with impairment within 3 mos; Youth has a medical or psychiatric disorder that is life-threatening or requires immediate hospitalization or emergency medical or therapeutic treatment; Evidence of recent sexual or physical abuse of the youth by legally responsible caregivers; Evidence of recent intimate partner violence between caregivers responsible for the youth's care.