Surgical Ablation of AF Efficacy Trial
Key facts
- Where
- Hamilton, CanadaSee the site
Where in Canada
- Hamilton General HospitalHamilton, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Population Health Research Institute
- Trial code
- NCT05434819
- Record updated
- 5 October 2026
- Original description
SAFE is an international multicentre RCT of concomitant surgical atrial fibrillation (AF) ablation in patients with paroxysmal or persistent AF undergoing cardiac surgery.Read full original descriptionShow less
SAFE is an international multicentre RCT of concomitant surgical atrial fibrillation (AF) ablation in patients with paroxysmal or persistent AF undergoing cardiac surgery.
Inclusion: Age ≥ 18 years; Undergoing a clinically indicated cardiac surgical procedure: CABG, AVR, ascending aorta replacement, or combinations thereof; Documented history of paroxysmal or persistent AF; Provide informed consent.
Exclusion: Previous cardiac surgery requiring opening of the pericardium; Dominant atrial arrhythmia is atrial flutter; Patients undergoing any of the following procedures:; Heart transplant; Complex congenital heart surgery; Sole indication for surgery is ventricular assist device insertion; Mitral valve repair or replacement; Tricuspid valve repair or replacement; Documented left atrial diameter ≥ 6 cm; Patient resides in a long-term care facility.