Dexamethasone before thyroid surgery in Graves disease and Hashimoto disease
Tests dexamethasone before surgery in adults with Graves disease or Hashimoto disease.
Key facts
- Who runs it
- Indiana University
- Where
- Indianapolis, United StatesSee the 3 sites
- Trial code
- Registry title
- Preoperative Corticosteroids in Autoimmune Thyroid Disease
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 76 people, planned
- Started
- 16 Jun 2023
- Expected to end
- 30 Jun 2027
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Dexamethasone
- Placebo
- Record updated
- 5 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Graves' disease or Hashimoto's disease who are about to have their whole thyroid removed. It tests whether a short course of corticosteroids before surgery reduces gland inflammation.
- Age
- 18 years and older.
- Sex
- All sexes can join.
- Disease stage
- Graves' disease or Hashimoto's disease (autoimmune thyroid disease), with total thyroidectomy (removal of the whole thyroid) planned.
- Earlier treatment
- People who had RAI (radioactive iodine) treatment or earlier neck surgery cannot join. People with recent steroid therapy cannot join.
- Biomarker or test result
- Positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb).
Main reasons for not taking part
- Known thyroid cancer
- Diabetes treated with medicines
- Earlier bad reaction to corticosteroids
- Taking any medicine that weakens the immune system, such as after an organ transplant or for another autoimmune disease
- Under 18 years old
The registry criteria, word for word
Show all 2 criteriaShow less
Other criteria
- Inclusion Criteria:; ■ Graves' disease or Hashimoto's disease with positive thyroid autoantibodies (TgAb, TPO, TSI, and/or TRAb) undergoing total thyroidectomy for their disease
- Exclusion Criteria:; Pediatric patients < 18; Prior treatment with RAI; Prior neck surgeries; Known diagnosis of thyroid cancer; Diabetic patients on medications; A history of adverse reactions to corticosteroids; Patients on any immunosuppressive regimen (such as organ transplant patients or patients treated for other autoimmune conditions). This includes patients with recent history of steroid therapy, or a history of adverse reactions to corticosteroids
Where in United States
- IU Health Methodist HospitalIndianapolis, United StatesContact: Robin GardinerTaking people
- IU Health North HospitalIndianapolis, United StatesContact: Robin GardinerTaking people
- IU Health University HospitalIndianapolis, United StatesContact: Robin GardinerTaking people
About the trial
What the trial wants to find out
This study proposes to randomize patients about to undergo surgery for their autoimmune, inflammatory thyroid disease, and determine if a short course of corticosteroids decreases the inflammation of the gland and makes surgery less difficult.
The 2 groups in the trial
- SteroidsTreatment being tested
Will be given pre-operative corticosteroid regimen
Treatment: Dexamethasone
- placeboPlacebo, for comparison
Will be given Placebo
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Randomized Controlled Trial of Preoperative Corticosteroids in Autoimmune ThyroidDisease
- Plain-language title
- Dexamethasone before thyroid surgery in Graves disease and Hashimoto diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 5 August 2026