Studies heart failure with preserved ejection fraction over many years
Follows adults with heart failure where the heart's pumping measure is normal.
Plain-language title generated from the registry record
Registry title: UK Heart Failure With Preserved Ejection Fraction
Key facts
- Where
- Abercynon, Aylesbury, Birmingham, Chelmsford, Dundee, Glasgow, Ipswich, Kettering, Leeds, Leicester, London, Manchester, Middlesbrough, Newcastle upon Tyne, Norwich, Nuneaton, Peterborough, Poole, Rhyl, Salisbury, Sheffield, Stockton-on-Tees, Sunderland, and Westcliff-on-Sea, United KingdomSee the 26 sites
Where in United Kingdom
- Cwm Taf Morgannwg University Health BoardAbercynon, United KingdomTaking people
- Buckinghamshire Healthcare NHS TrustAylesbury, United KingdomTaking people
- University Hospitals Birmingham NHS Foundation TrustBirmingham, United KingdomTaking people
- Broomfield HospitalChelmsford, United KingdomTaking people
- NHS TaysideDundee, United KingdomTaking people
- Glasgow Royal InfirmaryGlasgow, United KingdomTaking people
- West Suffolk NHS Foundation TrustIpswich, United KingdomTaking people
- Kettering General HospitalKettering, United KingdomTaking people
- Leeds Teaching Hospitals NHS TrustLeeds, United KingdomTaking people
- University Hospitals of Leicester NHS Foundation TrustLeicester, United KingdomTaking people
- Barnet HospitalLondon, United KingdomTaking people
- Guys and St Thomas NHS Foundation TrustLondon, United KingdomTaking people
- Imperial College Healthcare NHS TrustLondon, United KingdomTaking people
- Manchester University NHS Foundation TrustManchester, United KingdomTaking people
- The James Cook University HospitalMiddlesbrough, United KingdomTaking people
- Northumbria Healthcare NHS Foundation TrustNewcastle upon Tyne, United KingdomTaking people
- Norfolk & Norwich University Hospitals NHS Foundation TrustNorwich, United KingdomTaking people
- George Eliot HospitalNuneaton, United KingdomTaking people
- North West Anglia NHS Foundation TrustPeterborough, United KingdomTaking people
- University Hospitals Dorset NHS Foundation TrustPoole, United KingdomTaking people
- Betsi Cadwaldr University Health BoardRhyl, United KingdomTaking people
- Salisbury NHS Foundation TrustSalisbury, United KingdomTaking people
- Sheffield Teaching Hospitals NHS Foundation TrustSheffield, United KingdomTaking people
- University Hospital of North TeesStockton-on-Tees, United KingdomTaking people
- South Tyneside & Sunderland NHS Foundation TrustSunderland, United KingdomTaking people
- Southend University HospitalWestcliff-on-Sea, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Manchester University NHS Foundation Trust
- Trial code
- NCT05441839
- Record updated
- 6 May 2025
- Original description
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF.Read full original descriptionShow less
UK Heart Failure With Preserved Ejection Fraction Registry
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF.
HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited.
UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
Inclusion: Written informed consent; Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse; Natriuretic peptide levels measured.
Exclusion: LV EF < 40% (at screening or any previous measurement); Known active myocarditis, constrictive pericarditis, or cardiac tamponade; Known severe primary valvular heart disease; Known idiopathic, heritable or drug-induced pulmonary arterial hypertension; Heart transplantation or ventricular assist device; Complex congenital heart disease; Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis); Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy; Known arrhythmogenic right ventricular cardiomyopathy.