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Taking people in CanadaPhase 1

Tests deep brain stimulation for severe facial nerve pain

Tests deep brain stimulation for hard-to-treat facial pain in adults with a brain lesion.

Plain-language title generated from the registry record
Registry title: Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion

Key facts

Where
Sherbrooke, CanadaSee the site
Phase
Phase 1

Where in Canada

  • Centre hospitalier universitaire de Sherbrooke (CHUS)Sherbrooke, CanadaTaking people

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Trial details

Who runs it
Université de Sherbrooke
Trial code
NCT05451251
Record updated
12 December 2024
Original description
The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis.Read full original descriptionShow less

Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion: a Pilot Study

The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis.

These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief.

Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.

Inclusion: Adults of at least 18 years old; Refractory trigeminal neuralgia : failure of at least 3 drugs and at least two lesioning surgical interventions (radiosurgery, percutaneous rhizotomy, or open rhizotomy); Pontine lesion proved by MRI in contact with trigeminal nerve tract.

Exclusion: Absolute contraindication to MRI; Medical contraindication to the procedure.

ClinicalTrials.gov NCT05451251