Comparing two blood pressure pills for high blood pressure after childbirth
Compares nifedipine and labetalol tablets in new mothers with high blood pressure.
Key facts
- Who runs it
- Loma Linda University
- Where
- Loma Linda, United StatesSee the site
- Trial code
- Registry title
- Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
- Status
- Recruiting
- Phase
- Phase 3
- People taking part
- 500 people, planned
- Started
- 8 May 2023
- Expected to end
- Dec 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Oral Nifedipine
- Oral Labetalol
- Record updated
- 4 February 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women who have high blood pressure after giving birth and need medicine to control it. It compares two blood pressure medicines.
- Age
- 18 years or older
- Sex
- Women only
- Disease stage
- High blood pressure after delivery of the placenta that needs treatment, or long-term high blood pressure after birth that needs medicine. Treatment-level pressure means 140 or higher on top or 90 or higher on the bottom on at least 2 occasions at least 4 hours apart, or 160 or higher on top or above 110 on the bottom for more than 15 minutes.
Main reasons for not taking part
- History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block or pulmonary edema
- Cannot take Nifedipine or Labetalol
- Heart rate below 60 or above 110
- Native language other than English or Spanish
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Female
- Women who develop postpartum hypertension* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control; Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes
Who cannot take part
- History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
- Contraindication to either Nifedipine or Labetalol
- HR <60 or >110
- Native language other than English or Spanish
Where in United States
- Loma Linda University HealthLoma Linda, United StatesContact: Ashra TugungTaking people
About the trial
What the trial wants to find out
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
The 2 groups in the trial
- Oral NifedipineExisting treatment, for comparison
Participants will receive oral nifedipine for blood pressure control. Dosage may initially start at one 10mg capsule by mouth three times per 24 hours (total of 30mg a day), however dosage may be increased by 30mg increments (i.e. 20mg capsule three times a day for a total of 60mg a day). Maximum dosage for oral Nifedipine will be 120mg per day.
- Oral LabetalolExisting treatment, for comparison
Participants will receive oral labetalol for blood pressure control. Dosage may initially start at one 200mg tablet by mouth two times per 12 hours (total of 400mg every a day), however dosage may be increased by 100-200mg increments at a time. Maximum dosage for oral labetalol will be 2400mg per day.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Safest Choice of Antihypertensive Regimen for Postpartum Hypertension: A Randomized Control Trial (SCARPH)
- Plain-language title
- Comparing two blood pressure pills for high blood pressure after childbirthGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 4 February 2026