Azithromycin Before Anti-TNF Treatment in Crohn's Disease Patients
Tests azithromycin pills against placebo before anti-TNF therapy in adults with Crohn's disease.
Plain-language title generated from the registry record
Registry title: Pre-treatment With Azithromycin to Reduce Immunogenicity to to Anti-TNF Agents in Patients With Crohn's Disease
Key facts
- Where
- Beersheba, Haifa, Holon, Jerusalem, Kiryat Bialik, and Petah Tikva, IsraelSee the 9 sites
- Phase
- Phase 2
Where in Israel
- Soroka University Medical CenterBeersheba, IsraelTaking people
- Bnei ZionHaifa, IsraelTaking people
- Carmel Medical CenterHaifa, IsraelTaking people
- Rambam Health Care CampusHaifa, IsraelTaking people
- Wolfson Medical CenterHolon, IsraelTaking people
- Hadassah medical CenterJerusalem, IsraelTaking people
- Shaare ZedekJerusalem, IsraelTaking people
- ZvulunKiryat Bialik, IsraelTaking people
- Rabin Medical CenterPetah Tikva, IsraelTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Rambam Health Care Campus
- Trial code
- NCT05599347
- Record updated
- 29 July 2026
- Original description
This is a randomized placebo-controlled trial in Crohn's disease patients before initiation of anti-tumor necrosis factor-α (anti-TNF) therapy that aims to test the effect of a pre-treatment short course of azithromycin therapy on immunogenicityRead full original descriptionShow less
Pre-treatment With Azithromycin to Reduce Immunogenicity to Anti-Tumor Necrosis Factor-α Agents in Patients With Crohn's Disease
This is a randomized placebo-controlled trial in Crohn's disease patients before initiation of anti-tumor necrosis factor-α (anti-TNF) therapy that aims to test the effect of a pre-treatment short course of azithromycin therapy on immunogenicity
Inclusion: Ability to provide written informed consent prior to any study procedures and willing and able to attend all study visits, comply with the study procedures, read and write in order to complete questionnaires, and be able to complete the study period; Aged 18 to 80 years of age, inclusive, at the time of signing the informed consent; Diagnosis of CD with an onset of symptoms for a minimum of 3 months prior to Screening as determined by the investigator based on clinical history, exclusion of infectious causes, and characteristic endoscopic and histologic findings; Prior decision of starting infliximab or adalimumab therapy (including biosimilar drugs); Thiopurine and corticosteroid co-therapy will be permitted.
Exclusion: Patients on chronic antibiotic therapy due to any cause; Planned/ongoing methotrexate co-therapy; Fecal microbiota transplantation within 8 weeks prior to randomization; Patients who received azithromycin therapy in the previous year (we will not exclude prior use of other antibiotic therapy); Patients who received any antibiotic treatment within 4 weeks prior to randomization; Re-induction of the same anti-TNF medication; Patients who are on chronic therapy which cannot be withheld in one of these medications: colchicine, phenytoin, and digoxin; Patients with perianal involvement who are expected to require antibiotic therapy for their disease; Known history of allergy to the study intervention formulation or any of its excipients or components of the delivery device; Crohn's Disease complication requiring surgical treatment; Participant has any disorder that, in the opinion of the investigator, may compromise the ability to participate in the study; Prolonged QTc interval or conditions leading to additional risk for QT prolongation; Chronic kidney disease stage 5 (GFR < 10); Inclusion in another interventional study; Patients who cannot provide informed consent and do not have a legal guardian; Patients with ongoing fluid collection/abscess either internal or perianal; Pregnancy.