Compares stool testing with colonoscopy for checking colon polyps in older adults
Compares a stool test with colonoscopy to check for polyps in adults 65 to 82.
Plain-language title generated from the registry record
Registry title: Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Key facts
- Where
- Calgary, London, Vancouver, and Winnipeg, CanadaSee the 4 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 65-82 who have had colon polyps and are due for a follow-up colonoscopy. It compares a yearly stool test (FIT) with colonoscopy.
- Age
- 65 Years to 82 Years
- Sex
- All sexes can join.
- Disease stage
- History of colon polyps. The most recent colonoscopy found 2 or fewer non-advanced polyps. Due now or within 12 months for a colonoscopy.
Main reasons for not taking part
- History of colorectal cancer
- High-risk genetic syndrome for colorectal cancer, such as Lynch Syndrome, FAP or Serrated Polyposis Syndrome
- History of inflammatory bowel disease, such as ulcerative colitis or Crohn's disease
- Last colonoscopy found advanced polyps or 3 or more non-advanced polyps
- Serious illness that makes polyp follow-up unlikely to help, such as recent heart disease treatment, home oxygen use, recent stroke, severe kidney disease needing dialysis, or a new cancer in the last year
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 65 and 82 years old?
Source: NCT05612347, who can take part
Where in Canada
- University Of CalgaryCalgary, CanadaContact: Dr. Robert Hilsden, MDTaking people
- London Health Sciences Centre Research InstituteLondon, CanadaContact: Dr. Michael Sey, MDTaking people
- University of British ColumbiaVancouver, CanadaTaking people
- University of ManitobaWinnipeg, CanadaContact: Harminder Singh, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Dartmouth-Hitchcock Medical Center
- Trial code
- NCT05612347
- Record updated
- 2 October 2026
- Original description
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.Read full original descriptionShow less
Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
Inclusion: English or Spanish speaking; Personal history of colorectal polyps; Most recent colonoscopy with ≤2 non-advanced polyps; Currently due or coming due within 12 months for colonoscopy; Able to provide written informed consent.
Exclusion: Personal history of colorectal cancer; Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome); Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease); Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year); Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps; Patients unable to provide written informed consent.