Study to Evaluate of the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa

Who can take part

• Diagnosis of HS based on clinical history and physical examination for at least 3 months
• Diagnosis of HS (Hurley I or II) with the following:; A total AN count of 3 to ≤ 10, with no draining tunnels at screening and baseline visits. AND; The AN count at the screening AND baseline visits:
• AN of 3 should affect at least 1 distinct anatomical area
• AN of > 3 to ≤ 10 should affect at least 2 distinct anatomical areas
• Baseline Skin Pain or Itch NRS score ≥ 1
• Agreement to NOT use topical and systemic antibiotics for treatment of HS during the study
• Agreement to NOT use a diluted beach bath or topical antiseptic washes containing chlorhexidine gluconate or benzoyl peroxide on the areas affected by HS lesions during the study
• Willingness to avoid pregnancy or fathering children

Who cannot take part

• Use of any prohibited medications per protocol-defined criteria
• Concurrent conditions and history of other diseases:; Active ongoing inflammatory diseases of the skin other than HS that might confound the evaluation of HS; Any other concomitant skin disorder (eg, generalized erythroderma such as Netherton's syndrome), pigmentation, or extensive scarring that in the opinion of the investigator may interfere with the evaluation of HS AN or compromise participant safety; Immunocompromised (eg, lymphoma, acquired immunodeficiency syndrome, or Wiskott-Aldrich syndrome); Chronic or acute infection requiring treatment with systemic antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before baseline; Active acute bacterial, fungal, or viral skin infection (eg, herpes simplex, herpes zoster, chicken pox, clinically infected AD, or impetigo) within 2 weeks before baseline
• Laboratory values outside of the protocol-defined criteria
• Presence of draining tunnels at screening or at baseline visits
• Pregnant or lactating participants, or those considering pregnancy during the period of their study participation
• Other exclusion criteria may apply