A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Key facts
- Where
- Ahaus, Berlin, Bonn, Dresden, Essen, Frankfurt am Main, Hamburg, Kaiserslautern, Leipzig, Mannheim, Muenster, Munich, and Oldenburg, GermanySee the 14 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT05646381, who can take part
Where in Germany
- Klinikum Westmuensterland GmbHAhaus, GermanyTaking people
- Charite Universitaetsmedizin Berlin KöRBerlin, GermanyTaking people
- Universitaetsklinikum Bonn AöRBonn, GermanyTaking people
- Facharztzentrum Dresden-Neustadt Betriebsgesellschaft mbHDresden, GermanyTaking people
- Universitaetsklinikum Essen (AoR)Essen, GermanyTaking people
- ClinPhenomics CVC GmbHFrankfurt am Main, GermanyTaking people
- Asklepios Kliniken Hamburg GmbHHamburg, GermanyTaking people
- University Medical Center Hamburg-EppendorfHamburg, GermanyTaking people
- Kardiopraxis SchirmerKaiserslautern, GermanyTaking people
- Herzzentrum Leipzig GmbHLeipzig, GermanyTaking people
- ze:ro Praxen MVZ fuer Nierenerkrankungen und Bluthochdruck GmbH MannheimMannheim, GermanyTaking people
- Praxis für Innere MedizinMuenster, GermanyTaking people
- Deutsches Herzzentrum Muenchen Des Freistaates Bayern Klinik An Der Technischen Universitaet MuenchenMunich, GermanyTaking people
- Klinikum Oldenburg AorOldenburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Novartis Pharmaceuticals
- Trial code
- NCT05646381EU 2022-502135-19-00
- Record updated
- 23 June 2026
- Original description
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.Read full original descriptionShow less
A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis [Lp(a)FRONTIERS CAVS]
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
Inclusion: Male and female ≥50 to <80 years of age at Screening Part II; Lp(a) ≥175 nmol/L at the screening visit, measured at the Central laboratory; Mild or moderate calcific aortic valve stenosis; At the randomization visit, participant must be optimally treated for existing CV risk factors.
Exclusion: Uncontrolled hypertension; History of malignancy of any organ system; History of hemorrhagic stroke or other major bleeding; Active liver disease or hepatic dysfunction; Significant kidney disease; Platelet count ≤ LLN; Severe calcific aortic valve stenosis; Pregnant or nursing women; Other protocol-defined inclusion/exclusion criteria may apply.