Studying migraine in young teens through pain tests and brain scans
Studies migraine in children aged 10 to 13 using pain tests and brain scans.
Plain-language title generated from the registry record
Registry title: Migraine in Adolescents
Key facts
- Where
- St Louis, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 13 years old?
Source: NCT05654012, who can take part
Where in United States
- Washington University School of MedicineSt Louis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Washington University School of Medicine
- Trial code
- NCT05654012
- Record updated
- 13 July 2026
- Original description
Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescentsRead full original descriptionShow less
Migraine in Adolescents
Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescents
Aim 2a. To determine hormonal, psychophysical, and neural changes associated with migraine onset.
Aim 2b. To identify the temporal relationships between hormonal, psychophysical, and neural changes preceding vs. following migraine onset.
Aim 3. To identify psychophysical and neural factors predicting migraine prognosis in adolescents with migraine.
Inclusion: Age 10-13; Males or females (biological sex); Not diagnosed with migraine or having migraine symptoms; With a first degree relative diagnosed with migraine (for the Fam-His group) or without a first or a second degree relative diagnosed with migraine (for the No-Fam-His group); Age 10-13; Males or females (biological sex); Diagnosed with migraine or having migraine symptoms; Migraine duration > 6 months; Without preventative treatment or with stable preventative treatment for migraine (no change in intervention in the last 6 months).
Exclusion: Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:; Diagnosis of any chronic pain syndrome; Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder; Taking pain or psychiatric medications regularly; Having an MRI contraindication such as metal in the body or claustrophobia; Not able to understand and communicate in English; Participants will not be enrolled if any of the following criteria exist and based on the investigator discretion:; Diagnosis of any chronic pain syndrome other than migraine; Diagnosis of a neurological, developmental, pubertal, or psychiatric disorder; Having an MRI contraindication such as metal in the body or claustrophobia; Not able to understand and communicate in English.