Tracking Early Immune and Genetic Changes Before Inflammatory Bowel Disease Appears
Follows adults with early signs of Crohn disease or ulcerative colitis, collecting samples over time.
Plain-language title generated from the registry record
Registry title: Immunological Characteristics of Preclinical IBD
Key facts
- Where
- Alicante, Badalona, Barcelona, Bilbao, Burgos, Córdoba, Donostia / San Sebastian, Galdakao, Gijón, Madrid, Manresa, Ourense, Oviedo, San Cristóbal de La Laguna, Santiago de Compostela, Terrassa, Valencia, Valladolid, Vigo, and Zaragoza, SpainSee the 25 sites
Where in Spain
- Hospital General Universitario Dr. BalmisAlicante, SpainTaking people
- Hospital Universitario Germans Trias i PujolBadalona, SpainNot yet recruiting
- Hospital de Sant Joan Despí - Moises BroggiBarcelona, SpainTaking people
- Hospital Universitario de BasurtoBilbao, SpainTaking people
- Hospital Universitario De BurgosBurgos, SpainNot yet recruiting
- Hospital Universitario Reina SofiaCórdoba, SpainNot yet recruiting
- Hospital Universitario DonostiaDonostia / San Sebastian, SpainNot yet recruiting
- Hospital Universitario de GaldakaoGaldakao, SpainTaking people
- Hospital Universitario de CabueñesGijón, SpainTaking people
- Hospital Universitario de la PrincesaMadrid, SpainNot yet recruiting
- Hospital Universitario La PazMadrid, SpainNot yet recruiting
- Hospital Universitario Ramón y CajalMadrid, SpainNot yet recruiting
- Hospital General Universitario Gregorio MarañónMadrid, SpainNo longer taking part
- ALTHAIA, Xarxa Assistencial Universitaria de Manresa.Manresa, SpainNot yet recruiting
- Complejo Hospitalario Universitario de OurenseOurense, SpainNot yet recruiting
- Hospital Universitario Central De AsturiasOviedo, SpainNot yet recruiting
- Hospital Universitario de CanariasSan Cristóbal de La Laguna, SpainNot yet recruiting
- Hospital Clínico Universitario de SantiagoSantiago de Compostela, SpainTaking people
- Hospital Universitari Mútua de TerrassaTerrassa, SpainNot yet recruiting
- Hospital Univeristario y Politécnico La FeValencia, SpainNot yet recruiting
- Hospital Universitario Clínico de ValenciaValencia, SpainNot yet recruiting
- Hospital Universitario Rio HortegaValladolid, SpainNot yet recruiting
- Hospital Álvaro Cunqueiro (Complejo Hospitalario Universitario de Vigo)Vigo, SpainNot yet recruiting
- Hospital Clinico Universitario Lozano BlesaZaragoza, SpainNot yet recruiting
- Hospital Universitario Miguel ServetZaragoza, SpainNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
- Trial code
- NCT05698745
- Record updated
- 15 April 2026
- Original description
The purpose of this study is to evaluate disease progression, in terms of development of symptomatic disease and complications associated with IBD (e.g. fistula, abscess, stricture).Read full original descriptionShow less
Prospective Study of the Natural History, Immunological and Genetic Characteristics of Preclinical Inflammatory Bowel Disease
The purpose of this study is to evaluate disease progression, in terms of development of symptomatic disease and complications associated with IBD (e.g. fistula, abscess, stricture).
Inclusion: Patients from cohort A will be included if they fulfill all the following inclusion criteria:; Male or female ≥18 years of age at baseline; New diagnosis of IBD during a CRC screening colonoscopy, based on the criteria from the European Crohn's and Colitis Organization (33, 34); Presence of a chronic inflammatory infiltrate and histological diagnosis compatible with IBD; The patient must be asymptomatic at diagnosis and without previous symptoms suggestive of IBD; Time interval between the index colonoscopy and the baseline visit up to 3 months; Patients from cohort B will be included if they fulfill all the following inclusion criteria:; Male or female ≥18 years of age at baseline; Recent diagnosis of IBD, with <3 months from symptoms onset; Time interval between the index colonoscopy and the baseline visit up to 3 months; Patients from cohort C will be included if they fulfill all the following inclusion criteria:; Male or female ≥18 years of age at baseline; No endoscopic signs of IBD after a complete ileo-colonoscopy within the CRC screening program; Time interval between the index colonoscopy and the baseline visit up to 3 months.
Exclusion: Previous or current diagnosis of microscopic colitis; Previous use of immunomodulators or biologics for any condition; Patients from cohort C will be excluded if they fulfill any the following exclusion criteria:; Previous use of immunomodulators or biologics for any condition; Patients from cohort A will be excluded if they fulfill any the following exclusion criteria:; Identification of any enteropathogen in the stool culture; Isolated findings of acute inflammatory infiltrate without signs of chronicity; Alteration in biomarkers in blood or stool will not constitute an exclusion criterion; Patients from cohort B will be excluded if they fulfill any the following exclusion criteria:; Any gastrointestinal symptoms at baseline.