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Studies memory and thinking changes in people with prediabetes or type 2 diabetes

Observes memory and thinking changes in people with prediabetes or type 2 diabetes.

Key facts

Who runs it
Marinella Temprosa
Where
Albuquerque, Alhambra, Aurora, Baton Rouge, Boston, Chicago, Honolulu, Indianapolis, Lutherville, Memphis, Miami, New York, Philadelphia, Phoenix, Pittsburgh, Rockville, San Antonio, San Diego, Seattle, Shiprock, St Louis, The Bronx, Washington D.C., and Zuni, United StatesSee the 27 sites
Trial code
Registry title
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Status
Enrolling by invitation
People taking part
1,976 people, planned
Started
7 Nov 2022
Expected to end
30 Aug 2027
Type of study
Observational
Record updated
26 August 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for surviving people who were randomized in the original Diabetes Prevention Program. They have pre-diabetes or type 2 diabetes. A brain imaging group is also included.

Age
No age limit for the main study. The brain imaging group: 55 years and older.
Sex
All sexes can join.
Disease stage
Pre-diabetes or type 2 diabetes (people from the Diabetes Prevention Program).
Earlier treatment
Must have been randomized in the original Diabetes Prevention Program.

Main reasons for not taking part

  • Brain imaging group: cannot lie flat
  • Brain imaging group: claustrophobia
  • Brain imaging group: metal objects in the body that are not 3T MRI compatible

The registry criteria, word for word

Show all 3 criteriaShow less

Who can take part

  • All surviving participants originally randomized in the Diabetes Prevention Program
  • For Brain Imaging subcohort, only participants aged 55 years and older and those without contraindication to MRI will be included. Contraindications to MRI include the inability to lie flat, claustrophobia, and the presence of indwelling metallic objects, medical or non-medical, that are not 3T MRI compatible

Who cannot take part

  • -

Where in United States

  • University of New MexicoAlbuquerque, United StatesEnrolling by invitation
  • University of California Los AngelesAlhambra, United StatesEnrolling by invitation
  • University of ColoradoAurora, United StatesEnrolling by invitation
  • Pennington Biomedical CenterBaton Rouge, United StatesEnrolling by invitation
  • Joslin Diabetes CenterBoston, United StatesEnrolling by invitation
  • Massachusetts General HospitalBoston, United StatesEnrolling by invitation
  • Northwestern UniversityChicago, United StatesEnrolling by invitation
  • University of ChicagoChicago, United StatesEnrolling by invitation
  • University of HawaiiHonolulu, United StatesEnrolling by invitation
  • Indiana UniversityIndianapolis, United StatesEnrolling by invitation
  • Johns Hopkins UniversityLutherville, United StatesEnrolling by invitation
  • University of TennesseeMemphis, United StatesEnrolling by invitation
  • University of MiamiMiami, United StatesEnrolling by invitation
  • Columbia UniversityNew York, United StatesEnrolling by invitation
  • Columbia University Medical CenterNew York, United StatesEnrolling by invitation
  • Thomas Jefferson UniversityPhiladelphia, United StatesEnrolling by invitation
  • SW American Indian Center - PhoenixPhoenix, United StatesEnrolling by invitation
  • University of PittsburghPittsburgh, United StatesEnrolling by invitation
  • Biostatistics Center, George Washington UniversityRockville, United StatesEnrolling by invitation
  • University of Texas Health Science Center San AntonioSan Antonio, United StatesEnrolling by invitation
  • University of California San DiegoSan Diego, United StatesEnrolling by invitation
  • University of Washington, VA Puget Sound Health Care SystemSeattle, United StatesEnrolling by invitation
  • SW American Indian Center - ShiprockShiprock, United StatesEnrolling by invitation
  • Washington UniversitySt Louis, United StatesEnrolling by invitation
  • Albert Einstein College of MedicineThe Bronx, United StatesEnrolling by invitation
  • Medstar Health Research InstituteWashington D.C., United StatesEnrolling by invitation
  • SW American Indian Center - ZuniZuni, United StatesEnrolling by invitation

About the trial

What the trial wants to find out

The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer's Project Act goal to "prevent, halt, or reverse AD" in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Plain-language title
Studies memory and thinking changes in people with prediabetes or type 2 diabetesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
26 August 2025