Tests arm and leg endurance training for daily activities in COPD
Compares arm and leg training with leg-only training in people with COPD.
Plain-language title generated from the registry record
Registry title: Effect of Combined Endurance Training on ADL and Walking in COPD Patients
Key facts
- Where
- Lumezzane, Montescano, and Tradate, ItalySee the 3 sites
Where in Italy
- ICS Maugeri IRCCS, Respiratory Rehabilitation of the Institute of LumezzaneLumezzane, ItalyTaking people
- ICS Maugeri IRCCS, respiratory rehabilitation of the Institute of MontescanoMontescano, ItalyNot yet recruiting
- ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of TradateTradate, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituti Clinici Scientifici Maugeri SpA
- Trial code
- NCT05708443
- Record updated
- 24 June 2026
- Original description
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with related exercise intolerance and marked disability due to symptoms such as dyspnea and fatigue. Effort intolerance and exercise-induced symptoms cause marked impairment in completing activities of daily living (ADL). Pulmonary rehabilitation (PR), which has exercise as a major component, is considered a key treatment in the management of COPD since PR is effective in improving exercise tolerance, exercise-induced dyspnea and fatigue, and health-related quality of life. Rehabilitation is also effective in improving the time required to perform ADLs, reducing symptoms and disability. Studies show that rehabilitation protocols with upper limb exercises added to lower limb training are able to give additional benefits in terms of effort tolerance (endurance time at the arm ergometer and oxygen consumption) and reduction of dyspnea at iso-load.Read full original descriptionShow less
Effect of Combined Upper and Lower Extremity Endurance Training Versus Lower Extremity Training Alone on ADL and Walking in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease with related exercise intolerance and marked disability due to symptoms such as dyspnea and fatigue. Effort intolerance and exercise-induced symptoms cause marked impairment in completing activities of daily living (ADL). Pulmonary rehabilitation (PR), which has exercise as a major component, is considered a key treatment in the management of COPD since PR is effective in improving exercise tolerance, exercise-induced dyspnea and fatigue, and health-related quality of life. Rehabilitation is also effective in improving the time required to perform ADLs, reducing symptoms and disability. Studies show that rehabilitation protocols with upper limb exercises added to lower limb training are able to give additional benefits in terms of effort tolerance (endurance time at the arm ergometer and oxygen consumption) and reduction of dyspnea at iso-load.
The primary aim of this study is to evaluate whether the combined "arm and leg" training modality, compared to a gold standard protocol -involving only the lower limbs training- is more effective in improving ADL performance in terms of reduction of exercise time for a specific test (GLITTRE test).
Inclusion: GOLD class 2-3 COPD; Forced Expiratory Volume in the first second (FEV1) between 30% and 70% of the predicted value; ability to walk and climb stairs without assistance; stable clinical condition (pH > 7.35).
Exclusion: recent exacerbation (within 15 days) requiring a change in therapy; chronic respiratory insufficiency on long-term oxygen therapy (LTOT); cognitive impairment; presence of lung disease other than COPD; severe orthopedic, neurological or cardiological comorbidities; terminality.