Ultrasound Test for Liver Scarring in Adults With Fatty Liver Disease
Tests an endoscopic ultrasound scan for liver scarring in adults with fatty liver disease.
Key facts
- Who runs it
- Brigham and Women's Hospital
- Where
- Boston, United StatesSee the 2 sites
- Trial code
- Registry title
- Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease
- Status
- Recruiting
- People taking part
- 150 people, planned
- Started
- 1 Jun 2021
- Expected to end
- Jan 2027
- Type of study
- Observational
- Treatments tested
- Endoscopic ultrasound shear wave elastography
- Record updated
- 2 March 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a higher body weight and suspected or confirmed fatty liver disease. They are already planned for an endoscopic ultrasound and a liver biopsy.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Suspected or confirmed non-alcoholic fatty liver disease before the procedure.
- Biomarker or test result
- Body mass index of 25 or higher.
Main reasons for not taking part
- Inadequate liver biopsy sample
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Adults 18 years or older
- Planned for clinically indicated endoscopic ultrasound with plan for follow up liver biopsy
- Suspected or confirmed non alcoholic fatty liver disease prior to procedure
- Body mass index >=25
Who cannot take part
- Inadequate liver biopsy sample
Where in United States
- Brigham and Women's Faulkner HospitalBoston, United StatesContact: Peter Konyn, MDTaking people
- Brigham and Women's HospitalBoston, United StatesContact: Michele Ryan, MSTaking people
About the trial
What the trial wants to find out
The goal of this observation study is to assess whether endoscopic ultrasound shear wave elastography (EUS-SWE) may be a useful tool for liver fibrosis screening in patients with elevated body mass index and non alcoholic fatty liver disease as compared to other non-invasive screening modalities, which have traditionally had less accurate results in this population.
Read full original descriptionShow less
The main questions it aims to answer are:
* Determine accuracy of EUS-SWE for liver fibrosis screening compared to other non-invasive scoring systems, such as the FIB-4 score and Fibroscan in patients with elevated body mass index * Establish optimal stiffness (kPa) cutoffs for liver fibrosis grading for EUS-SWE for this patient population in reference to the gold standard liver biopsy, as no standard cutoffs currently exist.
Participants will undergo routine endoscopic ultrasound as part of their standard clinical care and indication. Participants are consented for the procedure and undergoing the shear wave elastography. In addition to their standard ultrasound test, it takes on average an extra 2-3 minutes to perform the shear wave elastography. The procedure itself adds no additional risk to the patient and does not expose them to radiation.
The group in the trial
- Patients with nonalcoholic fatty liver disease and elevated body mass index
Patients who have BMI \>=25 and suspected nonalcoholic fatty liver disease based on imaging, laboratory workup, or clinical history. Patients are included in the study if they have been selected for routine clinical endoscopic ultrasound (can be for any indication) with liver biopsy either during the same session or within 6 months.
Treatment: Endoscopic ultrasound shear wave elastography
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Endoscopic Ultrasound Shear Wave Elastography: A Novel Tool for Fibrosis Screening in Patient With Elevated Body Mass Index and Suspected Non-Alcoholic Fatty Liver Disease or Steatohepatitis
- Plain-language title
- Ultrasound Test for Liver Scarring in Adults With Fatty Liver DiseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 2 March 2026