Fatty liver disease (MASLD/MASH) trials in United States

In United States 101 Also abroad 367

101 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Endoscopic Ultrasound Shear Wave Elastography Study
Where
Boston, Danville, Newport Beach
Age
18 years and over
People
300
Run by
Olympus Corporation of the Americas
See details and how to joinNCT06592820
No phaseNot yet taking people in United States
Isocaloric Navy-Bean Substitution in Adults With MASLD
Where
New York
Age
18 years to 75 years
People
40
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07730853
No phaseTaking people
NAFLD Clinical Care Pathway
Where
Houston
Age
18 years to 80 years
People
32
Run by
VA Office of Research and Development
See details and how to joinNCT06671886
Phase 2Taking people
A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Akron, Apple Valley, Austin, Bellaire, Bradenton, Brownsville, Chandler, Columbia, Cordova, Corpus Christi, Covington, Dayton, Decatur, Edinburg, Farmers Branch, Fayetteville, Forney, Fort Worth, Fountain Valley, Garland, Georgetown, Glenview, Greenbelt, Gurnee, Houma, Houston, Jupiter, La Jolla, Lancaster, Las Vegas, Little Rock, Long Beach, Marietta, Marlton, Marrero, Metairie, Miami, Miami Lakes, Monroe, Ocala, Orange, Pasadena, Peoria, Port Orange, Richmond, San Antonio, Shreveport, South Bend, Sparta, Springboro, St Louis, Sugar Land, Tucson, Victorville, Viera, Waco, Webster, Westlake, West Monroe, West Palm Beach, Wichita Falls
Age
18 years to 75 years
People
160
Run by
Eccogene
See details and how to joinNCT07288138
Phase 2Taking people
Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Where
Arlington, Austin, Dallas, Danville, Doral, Fort Myers, Georgetown, Houston, Indianapolis, Marrero, Metairie, Miami, Nashville, Pasadena, Rialto, San Antonio, Sugar Land, Topeka, Tucson
Age
18 years to 75 years
People
360 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07631637 · EU 2026-525916-33-00
Phase 3Taking people
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Where
Amarillo, Atlanta, Aurora, Austin, Baltimore, Bastrop, Bellaire, Birmingham, Bradenton, Brandon, Brownsville, Buffalo, Chandler, Chapel Hill, Charleston, Charlotte, Chattanooga, Chicago, Chula Vista, Clarksville, Colorado Springs, Columbia, Columbus, Conway, Coronado, Corpus Christi, Covington, Dallas, Dayton, Denison, Doral, Dothan, Durham, Edinburg, Englewood, Escondido, Falls Church, Fayetteville, Flagstaff, Florham Park, Flowood, Folsom, Forney, Fort Myers, Fort Worth, Gainesville, Glen Burnie, Greenbelt, Hammond, Hermitage, Hershey, Hialeah Gardens, Houma, Houston, Indianapolis, Inglewood, Inverness, Jackson, Jacksonville, Jonesboro, Kansas City, Lady Lake, Lakewood Rch, La Mesa, Lancaster, Largo, Las Vegas, Lehigh Acres, Lewisville, Little Rock, Long Beach, Los Angeles, Louisville, Madison, Maitland, Manhasset, Margate, Marietta, Marrero, McAllen, Metairie, Miami, Miami Gardens, Miami Lakes, Morehead City, Naples, Nashville, New Bedford, New Bern, New Haven, New Orleans, Newport Beach, Newport News, New Port Richey, New York, Norfolk, North Little Rock, Novi, Ocala, Ogden, Orange, Orlando, Palm Springs, Pasadena, Pembroke Pines, Peoria, Philadelphia, Pittsburgh, Port Orange, Raleigh, Redwood City, Reno, Richmond, Ridgewood, Riverview, Roanoke, Rochester, Sacramento, Salt Lake City, San Antonio, San Diego, Sandy City, San Francisco, San Marcos, Santa Fe, Santa Maria, Sarasota, Seattle, Shreveport, Somers Point, South Bend, Southfield, South Ogden, Sparta, Spokane, Springboro, Statesville, St Louis, Suffolk, Summerville, Temple Terrace, Topeka, Tucson, Venice, Viera, Waco, Washington D.C., Webster, West Des Moines, Westlake, West Monroe, Weston, West Palm Beach, Wichita, Wichita Falls, Winter Park, Wyoming, Ypsilanti, Zephyrhills
Age
18 years to 80 years
People
1,650 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06215716
Phase 2Taking people
A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH
Where
Austin, Baltimore, Chandler, Dallas, Fayetteville, Fresno, Georgetown, Houston, Kansas City, Lancaster, Marietta, Mesa, Miami, New York, Pasadena, Pearland, Rialto, Richmond, San Antonio, Santa Maria, Tucson, Viera, Waco, Wilson
Age
18 years to 75 years
People
42
Run by
GlaxoSmithKline
See details and how to joinNCT06920043
Phase 1Taking people
A Study of Efimosfermin Alfa in Adults With Hepatic Impairment
Where
Houston, Miami Lakes, Rialto, San Antonio, Tampa
Age
18 years to 70 years
People
32
Run by
GlaxoSmithKline
See details and how to joinNCT07358546
Phase 3Taking people
A Pivotal Clinical Study to Investigate the Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Arlington, Austin, Bellaire, Cape Coral, Dallas, Folsom, Fort Myers, Hialeah, Homestead, Humble, Kissimmee, Lakeland, Little Rock, Manassas, Miami, Morehead City, New York, Ocala, San Antonio, Santa Maria, St Louis, University Park, Waco, West Jordan, Westlake
Age
18 years to 75 years
People
1,740 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07701993
Phase 3Taking people
A Study to Investigate Safety and Efficacy of Efimosfermin Compared With Placebo in Adult Participants With Compensated Cirrhosis Due to Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
Arcadia, Arlington, Arroyo Grande, Austin, Bellaire, Cape Coral, Dallas, East Syracuse, Folsom, Fort Myers, Hialeah, Homestead, Houston, Humble, Kissimmee, Lakeland, Little Rock, Manassas, Miami, Morehead City, New York, Ocala, San Antonio, Springboro, St Louis, University Park, Van Nuys, Waco, West Jordan, Westlake
Age
18 years to 75 years
People
380 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07704892
Phase 3Taking people
Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Where
Georgetown, Marrero, Metairie, Miami
Age
18 years to 75 years
People
1,500
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07854782 · EU 2026-526723-22-00
Phase 3Not yet taking people in United States
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Where
Albuquerque, Boston, Bristol, Dallas, Durham, Kansas City, Los Angeles, Oxnard, Pasadena, Peoria, Statesville, Summerville, Topeka, University Park, West Hills
Age
18 years and over
People
600 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07850063 · EU 2026-527091-88-00
Phase 3Taking people
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Where
Altamonte Springs, Arlington, Austin, Baltimore, Bastrop, Bellaire, Birmingham, Boston, Bradenton, Brandon, Bristol, Brooklyn, Brooksville, Brownsville, Canoga Park, Carrollton, Charleston, Chattanooga, Chesterfield, Chula Vista, Clarksville, Clearwater, Clermont, Clinton Township, Clive, Colorado Springs, Columbia, Columbus, Coral Gables, Coronado, Corpus Christi, Cutler Bay, Dallas, Denison, DeSoto, Durham, Edinburg, Englewood, Fayetteville, Flourtown, Flowood, Forney, Fort Myers, Fountain Valley, Fresno, Gainesville, Gardena, Garden City, Garland, Georgetown, Greenville, Hammond, Hershey, Hialeah, Hialeah Gardens, Homestead, Houston, Huntington Park, Inglewood, Kansas City, Lady Lake, Lakewood Rch, La Mesa, Lancaster, Las Vegas, Laurelton, Lewisville, Long Beach, Los Angeles, Macon, Maitland, Mansfield, Marrero, McAllen, Mentor, Miami, Miami Lakes, Minneapolis, Montclair, Naples, Nashville, New Bern, New Haven, Newport News, New York, Omaha, Orange, Orlando, Oxnard, Palmetto Bay, Pasadena, Pembroke Pines, Peoria, Plano, Port Orange, Poway, Raleigh, Rialto, Richmond, Riverdale, Riverview, Rochester, San Antonio, San Bernardino, San Diego, Santa Ana, Scottsdale, Seattle, Shreveport, South Bend, Spokane, Springboro, State College, St. Petersburg, Summerville, Tampa, The Villages, Topeka, Tucson, Tulsa, University Park, Van Nuys, Victorville, Waco, Warren Township, West Des Moines, Westlake, Wichita Falls, Winter Park, Wyoming, Wyomissing, Zephyrhills
Age
18 years and over
People
1,800 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632444 · EU 2024-513739-25-00
Phase 3Taking people
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Where
Arlington, Atlanta, Austin, Bastrop, Bellaire, Bradenton, Brandon, Bristol, Brooklyn, Brooksville, Brownsville, Canoga Park, Chattanooga, Chula Vista, Clarksville, Clinton Township, Colorado Springs, Columbia, Columbus, Coral Gables, Coronado, Cutler Bay, Dallas, Denison, Englewood, Fayetteville, Flourtown, Fort Myers, Fountain Valley, Garden City, Garland, Georgetown, Greenville, Hammond, Hershey, Hialeah, Hialeah Gardens, Homestead, Houston, Huntington Park, Inglewood, Kansas City, Lady Lake, La Mesa, Lancaster, Las Vegas, Laurelton, Lewisville, Macon, Mansfield, Marrero, McAllen, Mentor, Miami, Miami Lakes, Minneapolis, Montclair, Nashville, New Port Richey, New York, Omaha, Orange, Orlando, Oxnard, Palmetto Bay, Pembroke Pines, Peoria, Poway, Raleigh, Rialto, Richmond, Riverdale, Riverview, Rochester, San Antonio, San Bernardino, San Diego, Scottsdale, Seattle, Shreveport, South Bend, Spokane, Springboro, St. Petersburg, Summerville, Tampa, The Villages, Tucson, Tulsa, University Park, Waco, Warren Township, West Des Moines, Westlake, Wichita Falls, Winter Park, Wyoming, Wyomissing, Zephyrhills
Age
18 years and over
People
1,590 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632457 · EU 2024-513741-36-00
Phase 2Taking people
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)
Where
Bethesda
Age
18 years to 100 years
People
104
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT03884075
No phaseTaking people
Evaluation of Non-Invasive Tests for Metabolic Liver Disease
Where
Bellaire, Columbus, Miami, San Antonio
Age
18 years to 75 years
People
400
Run by
Foundation for the National Institutes of Health
See details and how to joinNCT07122700
Phase 3Taking people
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
Where
Akron, Albany, Albuquerque, Amarillo, Athens, Austin, Baltimore, Bellaire, Bellevue, Birmingham, Brandon, Brownsville, Burlington, Canoga Park, Carmel, Chandler, Charleston, Charlotte, Chattanooga, Chesterfield, Chicago, Clermont, Cleveland, Colorado Springs, Columbia, Conway, Cordova, Coronado, Corpus Christi, Covington, Dalton, Dayton, Denton, DeSoto, Durham, East Greenwich, Edinburg, Escondido, Farmers Branch, Fayetteville, Flagstaff, Florham Park, Flowood, Fort Myers, Fort Sam Houston, Fort Worth, Fountain Valley, Freehold, Fresno, Gardena, Garland, Georgetown, Glen Burnie, Glendale, Greenbelt, Hammond, Hermitage, Hialeah Gardens, Homestead, Houma, Houston, Huntington Park, Inglewood, Iowa City, Jacksonville, Jupiter, Katy, Lady Lake, La Jolla, Lake Charles, Lakewood Rch, Lancaster, Las Vegas, Lehigh Acres, Lewisville, Liberty Township, Lima, Little Rock, Littleton, Long Beach, Los Angeles, Louisville, Lubbock, Maitland, Maplewood, Marietta, Marrero, Miami, Montclair, Morehead City, Nashville, New Albany, New Orleans, New Port Richey, New York, North Little Rock, Ocala, Ocoee, Ogden, Orange, Panorama City, Pasadena, Poway, Raleigh, Rialto, Richmond, Roanoke, Rochester, San Antonio, Santa Ana, Sarasota, Seattle, South Bend, Southlake, Springboro, Stafford, Stanford, St Louis, Sugar Land, Sun City, Tacoma, Tomball, Topeka, Tucson, Tyler, Victorville, Waco, Warren Township, Westlake, West Monroe, Wilmington, Winston-Salem, Winter Park, Wyoming, Ypsilanti
Age
18 years to 80 years
People
1,350 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06318169 · EU 2023-509912-27-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Where
Akron, Albany, Albuquerque, Amarillo, Ann Arbor, Asheville, Athens, Atlanta, Austin, Baltimore, Bellevue, Birmingham, Brownsville, Burlington, Camarillo, Canoga Park, Chandler, Charleston, Charlotte, Chicago, Cincinnati, Clermont, Cleveland, Clinton Township, Columbia, Columbus, Cordova, Coronado, Dayton, DeSoto, Detroit, Durham, East Greenwich, Edinburg, Farmers Branch, Fayetteville, Flagstaff, Florham Park, Flowood, Fort Myers, Fort Worth, Fountain Valley, Framingham, Fresno, Gainesville, Georgetown, Glen Burnie, Glenview, Greenbelt, Greenville, Hammond, Harlingen, Hermitage, Hialeah Gardens, Homestead, Homewood, Houston, Huntington Park, Iowa City, Jacksonville, Kansas City, Lady Lake, Lafayette, La Jolla, Lake Charles, Lakewood Rch, Las Vegas, Lehigh Acres, Lewisville, Liberty Township, Little Rock, Littleton, Los Angeles, Louisville, Lubbock, Maitland, Mansfield, Marietta, Miami, Minneapolis, Nashville, New Albany, New Port Richey, New York, North Little Rock, Ocala, Ocoee, Orlando, Pasadena, Pearland, Peoria, Philadelphia, Phoenix, Pittsburgh, Poway, Rapid City, Redwood City, Rialto, Richmond, Rochester, Sacramento, San Antonio, Sandy City, San Marcos, Santa Ana, Seattle, Somers Point, South Bend, Southlake, St Louis, Sun City, Tacoma, Topeka, Tucson, Tupelo, Tyler, University Park, Viera, Waco, West Jordan, Westlake, West Monroe, Winston-Salem, Winter Park, Wyoming, Ypsilanti
Age
18 years to 75 years
People
1,800 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06419374 · EU 2023-510395-31-00
Phase 4Taking people
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
Where
Cleveland
Age
18 years to 70 years
People
70
Run by
The Cleveland Clinic
See details and how to joinNCT07058155
No phaseEnrolling by invitation
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Where
Columbia
Age
18 years to 80 years
People
750
Run by
University of Missouri-Columbia
See details and how to joinNCT04841057
Phase 1Taking people
Resmetirom in Patients With MASH and HFpEF
Where
Fort Myers, Oxnard, Peoria, Riverview, University Park
Age
18 years and over
People
90
Run by
Madrigal Pharmaceuticals, Inc.
See details and how to joinNCT07830758
Phase 4Taking people
Rezdiffra® With Concomitant Therapies Commonly Used to Treat Comorbidities in Adults With MASH and F2-F3 Fibrosis
Where
Arlington, Chandler, Chattanooga, Cincinnati, Coronado, Corpus Christi, Dallas, Lake Charles, Lakewood Rch, McAllen, Miami, Morehead City, North Little Rock, Rialto, San Antonio
Age
18 years and over
People
150
Run by
Madrigal Pharmaceuticals, Inc.
See details and how to joinNCT07848191
Phase 2Taking people
A Study to Test Whether BI 3802876 is Tolerated in People With Compensated Liver Cirrhosis Due to Metabolic Dysfunction- Associated Steatohepatitis (MASH)
Where
Arlington, Baltimore, Carrollton, Chandler, Charleston, Colorado Springs, Columbus, Coronado, Dallas, Fort Worth, Houston, Iowa City, Kansas City, La Mesa, Los Angeles, Miami, Miami Lakes, Montclair, Morehead City, Nashville, New York, Rochester, San Antonio, University Park
Age
18 years to 75 years
People
30 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07325526
Phase 3Taking people
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Where
Akron, Amarillo, Arlington, Atlanta, Aurora, Austin, Baltimore, Bastrop, Bellaire, Bethesda, Birmingham, Bradenton, Brandon, Brownsville, Buffalo, Chandler, Chapel Hill, Charleston, Charlotte, Chicago, Clarksville, Clinton Township, Colorado Springs, Columbia, Conway, Coronado, Corpus Christi, Covington, Cutler Bay, Dallas, Daytona Beach, Denison, Doral, Dothan, Durham, Edinburg, Englewood, Escondido, Fayetteville, Flagstaff, Flowood, Folsom, Fort Myers, Fort Sam Houston, Fort Worth, Fountain Valley, Gainesville, Garland, Hammond, Henderson, Hermitage, Hershey, Hialeah Gardens, Houma, Houston, Indianapolis, Inverness, Jackson, Jonesboro, Kansas City, Kingwood, Lady Lake, Lafayette, Lakewood Rch, Lancaster, Largo, Las Vegas, Lehigh Acres, Little Rock, Long Beach, Los Angeles, Louisville, Madison, Manhasset, Margate, Marietta, Marrero, Metairie, Miami, Miami Gardens, Morehead City, Naples, Nashville, New Haven, Newport Beach, New Port Richey, New York, Norfolk, North Little Rock, Novi, Ocala, Oklahoma City, Orange, Orlando, Pasadena, Pembroke Pines, Peoria, Pharr, Philadelphia, Pittsburgh, Raleigh, Redwood City, Richmond, Riverview, Roanoke, Rochester, Sacramento, San Antonio, San Francisco, San Jose, Sarasota, Scottsdale, Seattle, Shreveport, Snellville, Somers Point, South Bend, South Dartmouth, Southfield, Sparta, Springboro, Statesville, St Louis, Sugar Land, Summerville, Tarzana, Temple Terrace, Topeka, Tucson, Vancouver, Venice, Viera, Waco, Washington D.C., Webster, West Des Moines, Westlake, West Monroe, Weston, Wichita Falls, Zephyrhills
Age
18 years to 80 years
People
2,150 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06528314
No phaseNot yet taking people in United States
AGED Diagnostics Clinical Validation Study
Where
Bethesda
Age
18 years to 75 years
People
500
Run by
Active Genomes Expressed Diagnostics, Corp
See details and how to joinNCT07867574