Tests magnesium against saline during cancer surgery with cisplatin
Tests magnesium against saline in adults with mesothelioma receiving cisplatin during surgery.
Plain-language title generated from the registry record
Registry title: MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI
Key facts
- Where
- Boston, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Brigham and Women's HospitalBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Brigham and Women's Hospital
- Trial code
- NCT05730816
- Record updated
- 21 November 2025
- Original description
In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin compared to placeboRead full original descriptionShow less
MAGIC-AKI: Magnesium for the Prevention of Hyperthermic Intraoperative Cisplatin-Associated AKI
In this research study, investigators will test whether prophylactic high-dose IV Mg administration attenuates the risk of AKI in patients with malignant mesothelioma receiving intraoperative chemotherapy (HIOC) with cisplatin compared to placebo
.
Inclusion: • Adult patients (≥18 years old) with malignant mesothelioma undergoing surgery with HIOC with Dr. Raphael Bueno or another BWH thoracic surgeon.
Exclusion: Coronary artery disease, defined as any of the following in the prior year: a positive stress test; coronary angiogram indicating 1 or more vessels with >70% stenosis; percutaneous coronary intervention with stents; or coronary artery bypass graft surgery; Positive COVID test in the 10 days prior to surgery; Concurrent participation in a study with an alternative experimental therapy that may interact with IV Mg; Neuromuscular disease (e.g., myasthenia gravis, amyotrophic lateral sclerosis, multiple sclerosis, muscular dystrophy, myositis); Sinus bradycardia, defined as a heart rate (HR) <55 beats per minute (bpm) detected on any ECG in the preceding 6 months; Hypersensitivity to Mg sulfate; Any condition that, in the view of the PI, might place the patient at increased risk or compromise the integrity of the study; eGFR<45 ml/min/1.73m2 on either screening labs or preoperative labs, or end-stage kidney disease receiving renal replacement therapy. Screening labs refer to those obtained at the preoperative visit with the surgeon or within 90 days prior, whereas preoperative labs are obtained on the day of admission (typically one to three days priors to surgery); Serum Mg >3 mg/dl on either screening labs or preoperative labs; Pregnant/breastfeeding; High grade AV block (2nd degree AV block type II or 3rd degree AV block) without a pacemaker; Prisoner; Conflict with other study.