Mesothelioma trials in United States

In United States 54 Also abroad 104

54 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Where
Bethesda
Age
18 years to 120 years
People
60
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04847063
No phaseTaking people
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma
Where
Bethesda
Age
2 years to 100 years
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT01950572
Phase 1Taking people
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Where
Bethesda
Age
18 years to 120 years
People
120
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06885697
Phase 1/2Taking people
A 2-part Phase 1/2 Open-label Trial on ODM-212
Where
Fairfax, Fort Worth, Irving, Los Angeles, Orange
Age
18 years and over
People
229 worldwide
Run by
Orion Corporation, Orion Pharma
See details and how to joinNCT07563738
Phase 1/2Taking people
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Where
Albuquerque, Englewood, Florham Park, Fort Lauderdale, Hartford, Houston, Morristown, New York, Pembroke Pines, Santa Rosa, Washington D.C., York
Age
18 years to 80 years
People
242 worldwide
Run by
VM Oncology, LLC
See details and how to joinNCT03556228
Phase 1/2Taking people
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
Where
Abilene, Augusta, Austin, Boston, Camden, Columbus, Dallas, Detroit, Doylestown, Eugene, Everett, Fairfax, Fort Myers, Fort Worth, Grand Rapids, Los Angeles, Maplewood, Nashville, Norfolk, Oklahoma City, Phoenix, Pittsburgh, Portland, Providence, Rockville, San Diego, Santa Barbara, Santa Rosa, St. Petersburg, Tucson, Tyler, West Palm Beach, West Valley City, Westwood, Woodland
Age
18 years and over
People
952 worldwide
Run by
Genmab
See details and how to joinNCT05579366
Phase 1Taking people
SW-682 in Advanced Solid Tumors
Where
Cleveland, Dallas, Houston, Los Angeles, Portland, Sacramento, Santa Monica, Scottsdale
Age
18 years and over
People
186
Run by
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
See details and how to joinNCT06251310
No phaseTaking people
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Where
Bethesda
Age
30 years to 120 years
People
300
Run by
National Cancer Institute (NCI)
See details and how to joinNCT04431024
Phase 2Taking people
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Where
Bethesda
Age
18 years to 120 years
People
320
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06503146
Phase 1/2Taking people
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Where
Cleveland, Columbus, Dallas, Houston, Kansas City, Lexington, Los Angeles, Madison, Miami, New York, Omaha, Pittsburgh, Rochester, St Louis
Age
18 years to 90 years
People
112
Run by
Perspective Therapeutics
See details and how to joinNCT06710756
No phaseTaking people
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
Where
Boston, Columbus, Duarte, Gilbert, Houston, Jacksonville, La Jolla, Nashville, New York, Palo Alto, Phoenix, Rochester, Santa Monica, Seattle, St Louis, Tampa
Age
18 years and over
People
500
Run by
A2 Biotherapeutics Inc.
See details and how to joinNCT04981119
Phase 2Taking people
Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma
Where
Appleton, Bemidji, Bismarck, Chicago, Columbus, Conroe, Coon Rapids, Danville, Eau Claire, Edina, Effingham, Fargo, Fridley, Houston, League City, Lexington, Marshfield, Mattoon, Minneapolis, Minocqua, Oklahoma City, Phoenix, Pittsburgh, Rice Lake, Rochester, Saint Louis Park, Saint Paul, Sioux Falls, Stevens Point, Sugar Land, Urbana, Weston, Willmar, Worthington
Age
18 years and over
People
66
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05001880
Phase 1Taking people
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
Where
Houston, San Antonio, Scottsdale
Age
18 years and over
People
30
Run by
SHY Therapeutics
See details and how to joinNCT07705334
No phaseTaking people
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1
Where
Bethesda
Age
2 years to 120 years
People
1,000
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03830229
No phaseTaking people
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome
Where
Columbus
People
500
Run by
Mohamed Abdel-Rahman
See details and how to joinNCT04792463
Phase 2Taking people
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma
Where
Bethesda
Age
18 years to 120 years
People
15
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05960773
No phaseTaking people
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
Where
Bethesda
Age
2 years to 120 years
People
1,559
Run by
National Cancer Institute (NCI)
See details and how to joinNCT00242723
Phase 1/2Taking people
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
Where
Boston, Denver, Houston, Miami, Nashville, San Antonio
Age
18 years and over
People
330
Run by
ModeX Therapeutics, An OPKO Health Company
See details and how to joinNCT06239194
Phase 1Taking people
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer or Malignant Peritoneal Mesothelioma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
32
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06623396
Phase 1/2Taking people
Neoadjuvant Durvalumab and Tremelimumab With and Without Chemotherapy for Mesothelioma
Where
Durham, Houston
Age
18 years and over
People
52
Run by
Baylor College of Medicine
See details and how to joinNCT05932199
Phase 1Taking people
A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
Where
Coral Springs, Duarte, East Brunswick, Fairfax, Fort Worth, Goodyear, Houston, Irving, Jacksonville, Nashville, New York, Omaha, Orlando, Philadelphia, Phoenix, Rochester, Santa Rosa, Seattle, Tampa, Washington D.C., West Valley City, Zion
Age
18 years and over
People
260
Run by
IDEAYA Biosciences
See details and how to joinNCT07277413
No phaseTaking people
Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
30 years to 85 years
People
20
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06037941
Phase 2Taking people
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Where
Ann Arbor, Basking Ridge, Chicago, Commack, Harrison, Middletown, Montvale, New Brunswick, New York, Omaha, Pittsburgh, St Louis, Uniondale
Age
18 years and over
People
64
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT06057935
Phase 1/2Taking people
Study of ISM6331 in Participants With Advanced/Metastatic Mesothelioma or Other Advanced Solid Tumors
Where
Austin, Chicago, Cleveland, Denver, Nashville, Philadelphia
Age
18 years and over
People
160 worldwide
Run by
InSilico Medicine Hong Kong Limited
See details and how to joinNCT06566079
Phase 1Taking people
A Study of BMS-986504 With Standard-of-Care Therapy for People With Solid Tumor Cancer
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Uniondale
Age
18 years and over
People
60
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT07532902