WithdrawnNo phase
Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve
Key facts
- Who runs it
- Vanderbilt University Medical Center
- Where
- Nashville, United StatesSee the site
- Trial code
- Status
- Withdrawn
- Started
- Dec 2025
- Expected to end
- Mar 2028
- Type of study
- Interventional
- Treatments tested
- Nerve stimulation using nerve stimulation device and sterile wire electrode.
- Record updated
- 1 October 2025
- Why it stopped
- No participants have been enrolled to date.
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Consenting adults with BMI ≥ 25 and ≤ 40 kg/m2
- Planned resection of parapharyngeal space (PPS) mass without clinical evidence of cranial nerve function deficits based on physical examination
- History of moderate-to-severe Obstructive Sleep Apnea (OSA) as confirmed by previous polysomnogram OR high risk for OSA based on STOP-BANG criteria (STOP-BANG score ≥ 3)
Who cannot take part
- Previous pharyngeal surgery excluding tonsillectomy (e.g. cleft palate repair, uvulopalatopharyngoplasty)
- Prior history of head and/or neck chemoradiation therapy
- Unable to consent for research due to a pre-existing neurologic condition or language barriers as determined by PI
- History of other primary sleep-related breathing disorder (e.g., central, or complex sleep apnea)
- Existing indwelling neurostimulation device (e.g. pacemaker; spinal, vagal, or hypoglossal nerve stimulator)
Where in United States
- Vanderbilt University Medical CenterNashville, United StatesNo longer taking part
About the trial
What the trial wants to find out
Published data suggest that the glossopharyngeal nerve innervates pharyngeal musculature important for maintenance of upper airway patency. The investigators propose a study examining the anatomic variation of the glossopharyngeal nerve and the effect of electrical stimulation on muscle recruitment and upper airway patency.
The group in the trial
- Surgical ProcedureOther group
Consented patients who meet eligibility will have a surgical procedure for management of head and neck cancer, with dissection and exposure of the relevant anatomic structures as part of regular clinical care.
Treatment: Nerve stimulation using nerve stimulation device and sterile wire electrode.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 1 October 2025