Head and neck cancer trials in United States

In United States 387 Also abroad 942

387 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
Where
Nashville, Philadelphia
Age
18 years and over
People
204
Run by
Abramson Cancer Center at Penn Medicine
See details and how to joinNCT06125743
Phase 1/2Taking people
A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
Where
Orlando, Tampa, Tulsa
Age
18 years and over
People
72
Run by
Theravectys S.A.
See details and how to joinNCT06319963
No phaseTaking people
Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers
Where
Duarte
Age
18 years and over
People
40
Run by
City of Hope Medical Center
See details and how to joinNCT06985784
Phase 1Taking people
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Where
Austin, Celebration, Denver, Detroit, Duarte, East Brunswick, Fairfax, Fort Worth, Houston, Irvine, Irving, Lake Success, Nashville, New Haven, New York, Plantation, San Antonio, Sarasota, Spokane, West Valley City
Age
18 years and over
People
150 worldwide
Run by
IDEAYA Biosciences
See details and how to joinNCT07503808 · EU 2026-526299-21-00
Phase 2Taking people
Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients
Where
Pittsburgh
Age
18 years and over
People
40
Run by
Matthew Spector
See details and how to joinNCT07631650
Phase 1/2Taking people
Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate Cancer
Where
Bethesda
Age
18 years to 120 years
People
120
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07667400
No phaseNot yet taking people in United States
MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on Treatment
Where
Detroit
Age
18 years to 70 years
People
100
Run by
Barbara Ann Karmanos Cancer Institute
See details and how to joinNCT07928154
Phase 2Taking people
Indocyanine Green With Near Infrared Imaging for Intraoperative Visualization of Head and Neck Squamous Cell Carcinoma
Where
St Louis
Age
18 years and over
People
25
Run by
Washington University School of Medicine
See details and how to joinNCT07825597
Phase 2Not yet taking people in United States
Induction Chemoimmunotherapy to Prevent Laryngectomy in Advanced Laryngeal Cancer and Hypopharyngeal Cancer
Where
Rochester
Age
18 years and over
People
50
Run by
Mayo Clinic
See details and how to joinNCT07923877
No phaseNot yet taking people in United States
Removing the Planning Tumor Volume From Radiation Therapy for the Treatment of Head and Neck Squamous Cell Carcinoma
Where
Duarte
Age
18 years and over
People
30
Run by
City of Hope Medical Center
See details and how to joinNCT07926906
Phase 1/2Taking people
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
Where
Allentown, Atlanta, Billings, Camden, Chicago, Clermont, Cleveland, Dallas, Detroit, Duarte, El Paso, Fairfax, Glendale, Grand Island, Grand Rapids, Iowa City, Knoxville, La Jolla, Lakewood, Los Angeles, Louisville, Milwaukee, Murrieta, Nashville, Omaha, Orange City, Portland, Saint Louis Park, Saint Paul, San Antonio, Santa Rosa, St Louis, The Bronx, The Woodlands, Tyler
Age
18 years and over
People
340 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT04198766
No phaseTaking people
A Study of Neurocognitive Tests and Questionnaires for People With Head and Neck Cancer Who Are Undergoing Radiation Therapy
Where
Basking Ridge, Commack, Harrison, Middletown, Montvale, New York, Rockville Centre
Age
18 years to 89 years
People
185
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05207098
Phase 3Taking people
Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
Where
Allentown, Ames, Anaconda, Ann Arbor, Aventura, Baltimore, Barrington, Basking Ridge, Bemidji, Bethlehem, Billings, Bismarck, Boise, Boone, Boston, Bozeman, Brighton, Burlington, Burnsville, Caldwell, Canton, Cape Girardeau, Carlisle, Cedar Rapids, Centerville, Chapel Hill, Charleston, Chelsea, Cherry Hill, Chicago, City of Saint Peters, Coeur d'Alene, Colorado Springs, Commack, Coon Rapids, Creve Coeur, Crown Point, Crystal Lake, Cudahy, Danville, Dayton, Decatur, Downers Grove, East Stroudsburg, Eau Claire, Edina, Effingham, Elgin, Erie, Fargo, Flint, Fort Collins, Fort Dodge, Franklin, Germantown, Glens Falls, Golden, Grafton, Great Falls, Greeley, Green Bay, Greensburg, Greenville, Harrisburg, Harrison, Hays, Hazel Crest, Hendersonville, Indiana, Jefferson, Johnstown, Kalispell, Kansas City, Kenosha, La Crosse, Lansing, Lawrence, Lawton, Lebanon, Lee's Summit, Liberty, Libertyville, Little Rock, Livonia, Loveland, Macomb, Maplewood, Marinette, Marshalltown, Marshfield, Marysville, Mattoon, Mechanicsburg, Miami Beach, Middletown, Milwaukee, Minneapolis, Missoula, Mitchell, Monroeville, Montvale, Mukwonago, Nampa, New Lenox, New York, Normal, Oak Lawn, Oconomowoc, O'Fallon, Oklahoma City, Olathe, Ontario, Oregon City, Orland Park, Osage Beach, Oshkosh, Overland Park, Palo Alto, Palos Heights, Park Ridge, Peoria, Philadelphia, Pierre, Pinehurst, Pittsburgh, Pontiac, Portland, Post Falls, Racine, Rice Lake, Richmond, Rockford, Saint Johnsbury, Saint Louis Park, Saint Paul, Salina, Sandpoint, Seneca, Sewell, Sheboygan, Shiloh, Sioux Falls, Springfield, Stevens Point, St Louis, Summit, Sylvania, Syracuse, Topeka, Troy, Two Rivers, Uniondale, Uniontown, Urbana, Verona, Washington, Waukesha, Wauwatosa, West Allis, Weston, Westwood, Yankton, Ypsilanti
Age
18 years and over
People
158
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06589804
Phase 2Taking people
A Single Arm Phase II Trial in p16-positive Oropharynx Cancer of Selective Dose De-escalation of nodAl VolumEs at Minimal Risk and Primary Site Disease (SAVED)
Where
Baltimore, Columbia, Glen Burnie
Age
18 years and over
People
132
Run by
University of Maryland, Baltimore
See details and how to joinNCT07418034
Phase 2Taking people
Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial
Where
Rochester
Age
18 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT07783581
Phase 1Taking people
Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
Where
Chapel Hill
Age
18 years and over
People
33
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT06096038
Phase 1Taking people
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Where
Boston, Conroe, Duarte, Houston, Irvine, League City, Los Angeles, Nashville, New Haven, Newton, San Antonio, Santa Monica, Sugar Land, Trumbull
Age
18 years and over
People
540 worldwide
Run by
Pfizer
See details and how to joinNCT07090499 · EU 2025-521729-33-00
No phaseNot yet taking people in United States
Gut-Liver-Muscle Axis in Cancer Cachexia
Where
Aurora
Age
40 years to 89 years
People
20
Run by
University of Colorado, Denver
See details and how to joinNCT07911150
Phase 1/2Taking people
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Where
Albuquerque, Englewood, Florham Park, Fort Lauderdale, Hartford, Houston, Morristown, New York, Pembroke Pines, Santa Rosa, Washington D.C., York
Age
18 years to 80 years
People
242 worldwide
Run by
VM Oncology, LLC
See details and how to joinNCT03556228
No phaseTaking people
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
Where
Austin, Charleston, Cleveland, Corbin, Duarte, Elizabethtown, Florence, Gainesville, Lexington, Memphis, Miami, Minneapolis, Nashville, New Albany, Paducah, Portland, Rochester
Age
40 years and over
People
7,000
Run by
Adela, Inc
See details and how to joinNCT05366881
Phase 1Taking people
A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Where
Athens, Birmingham, Boston, Buffalo, Fort Wayne, Margate, Nashville, Orlando, Palo Alto, Sarasota, Spokane
Age
18 years and over
People
85
Run by
Compass Therapeutics
See details and how to joinNCT06150664
Phase 1Taking people
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Where
Atlanta, Boston, Chicago, Cleveland, Denver, Duarte, Grand Rapids, Houston, Indianapolis, La Jolla, Los Angeles, Nashville, New York, Salt Lake City, San Antonio, St Louis, St. Petersburg, West Valley City
Age
18 years and over
People
460 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06465069 · EU 2024-512927-36-00
Early phase 1Taking people
PET/CT Assessment of Radiation-Induced Vascular Complications in Head and Neck Cancer
Where
Atlanta
Age
18 years and over
People
20
Run by
Emory University
See details and how to joinNCT06914999
Phase 3Taking people
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
Where
Albert Lea, Ames, Anaconda, Antigo, Augusta, Aurora, Bakersfield, Barrington, Bath, Bellevue, Bemidji, Billings, Bismarck, Bloomington, Boise, Boone, Bozeman, Bridgeport, Brunswick, Buffalo, Burlington, Canton, Cape Girardeau, Carthage, Cedar Rapids, Cherry Hill, Cheyenne, Chicago, Clive, Coeur d'Alene, Colorado Springs, Columbus, Council Bluffs, Crystal Lake, Cudahy, Damariscotta, Danville, Decatur, Denver, Des Moines, Dickson City, Dixon, Downers Grove, Dublin, Eau Claire, Effingham, Elgin, Erie, Eureka, Fargo, Farmington, Farrell, Forest Hills, Fort Dodge, Fremont, Fresno, Fruitland, Galesburg, Germantown, Gilbert, Grafton, Great Falls, Green Bay, Greensburg, Greer, Harrisburg, Hazel Crest, Honolulu, Jefferson, Jefferson Hills, Joplin, Kalispell, Kearney, Kenosha, Kewanee, La Crosse, Lafayette, Lake Success, Lakewood, Lewisburg, Libertyville, Little Rock, Lone Tree, Los Angeles, Macomb, Mankato, Marinette, Marshalltown, Martinsburg, Mattoon, Mechanicsburg, Medford, Menomonee Falls, Meridian, Milwaukee, Missoula, Modesto, Moline, Monroeville, Morgantown, Mount Vernon, Nampa, Newport News, New York, Normal, Oak Creek, Oakland, Oak Lawn, O'Fallon, Oklahoma City, Omaha, Oshkosh, Ottawa, Palos Heights, Parkersburg, Park Ridge, Pekin, Peoria, Peru, Philadelphia, Phoenix, Pittsburgh, Portland, Post Falls, Pottsville, Princeton, Racine, Rego Park, Rhinelander, Rochester, Roseville, Sacramento, Saint Cloud, Salt Lake City, Sandpoint, Sanford, San Francisco, San Jose, San Leandro, San Rafael, Santa Clara, Santa Rosa, Scarborough, Scottsdale, Seneca, Sewell, Sheboygan, Sioux Falls, South Jordan, South Portland, South San Francisco, Spartanburg, Springfield, Stevens Point, St Louis, Stony Brook, Summit, Surprise, Tempe, The Bronx, Two Rivers, Urbana, Vallejo, Walnut Creek, Washington, Wausau, Wauwatosa, West Allis, West Bend, Wexford, Wheeling, Wilkes-Barre, Willow Grove, Wisconsin Rapids
Age
18 years and over
People
228
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT06992427
No phaseTaking people
Distance-Based Exercise to Preserve Function and Prevent Disability
Where
Boston, Butler, Cranberry Township, Dublin, Fremont, Fresno, Indiana, Kernersville, Mechanicsville, Midlothian, Modesto, Mount Airy, New Castle, Oakland, Pittsburgh, Richmond, Sacramento, San Francisco, San Jose, San Rafael, Santa Clara, Santa Rosa, Seneca, Vallejo, Walnut Creek, Winston-Salem
Age
18 years and over
People
104
Run by
Alliance for Clinical Trials in Oncology
See details and how to joinNCT07059884