Tests a imaging method to check inflamed bowel edges in Crohn's ileal disease

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with Crohn's disease who need surgery to remove part of the ileum and caecum. Cellvizio is used during the operation to look at the cut edges.

Age

18 years or older

Sex

All sexes can join.

Disease stage

Crohn's disease of any type that needs an ileocaecal resection (removal of the end of the small bowel and the start of the large bowel).

Earlier treatment

People who had an ileocolic resection for a return of Crohn's disease after surgery cannot join.

Main reasons for not taking part

• Under 18 years old
• Pregnancy or breastfeeding
• Ileocolic resection for a return of Crohn's disease after surgery
• Emergency surgery for peritonitis
• Cannot have a fluorescein injection, or severe allergy to any drug

The registry criteria, word for word

What the trial wants to find out

Crohn disease is an inflammatory bowel disease. A surgical procedure is required in about 80% of cases. Surgery doesn't cure from Crohn's disease but the type of surgery remains important as there are several intraoperative risk factors for recurrence. Among these factors the microscopic inflammation at the resection margins. This is a crucial point, if the resection is too large there is a risk of short bowel syndrome, if the resection is too short (microscopic inflammation at resection site), there is a higher risk of postoperative recurrence (75% vs 46% at 18 months). Surgeons have to do a limited resection (2cm from macroscopic crohn disease). However this macroscopic non inflammatory resection margin can be microscopically inflammatory (up to 80%). Thus it is useful to evaluate if there is a microscopic inflammation at the resection margin. Moreover there is an increase interest for the role of the mesentery for recurrence but its role remains unclear. It is of interest to clarify the border between the inflammatory and non-inflammatory mesentery. Cellvizio is a confocal laser endomicroscopy providing the possibility of obtaining in vivo high-magnification images of the gut epithelium. This allows real-time examination of the gastrointestinal mucosa at the cellular and subcellular level. Cellvizio has never been used during surgery for Crohn disease.

The group in the trial

• CellvizioTreatment being tested

  Cellvizio is a confocal laser endomicroscopy providing the possibility of obtaining in vivo high-magnification images of the gut epithelium. This allows real-time examination of the gastrointestinal mucosa at the cellular and subcellular level