Active, not recruitingNo phase
GAE Using Embosphere Microspheres vs Corticosteroid Injections for Treatment of Symptomatic Knee OA (MOTION)
Key facts
- Who runs it
- Merit Medical Systems, Inc.
- Where
- Atlanta, Boston, Chicago, College Park, Columbus, Falls Church, Galloway, Leesburg, Long Beach, Manhasset, New York, Newark, Oklahoma City, Raleigh, Sanford, St Louis, Washington D.C., and Williamsville, United StatesSee the 19 sitesAlso in 5 other countries, 8 sites
- Trial code
- Status
- Active, not recruiting
- People taking part
- 264 people, planned
- Started
- 16 Jan 2024
- Expected to end
- Oct 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Embosphere Microspheres
- Corticosteroid injection
- Record updated
- 24 October 2025
Who can take part
- Age
- 21 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Provides written informed consent
- Age ≥21 years
- Mild to severe knee pain, defined as a WOMAC Pain score of ≥8 out of 20 (in the target knee)
- Pain refractory to conservative therapies for at least 90 days prior to enrollment/randomization
- Kellgren-Lawrence grade 1, 2, 3 or 4
Who cannot take part
- Planned major surgical or endovascular procedures ≤ 30 days after the index procedure
- Prior knee replacement surgery of the target knee
- Known history of rheumatoid or infectious arthritis
- Advanced atherosclerosis
Where in United States
Also in 5 other countries, 8 sites
- Emory University School of MedicineAtlanta, United StatesNo longer taking part
- Massachusetts General HospitalBoston, United StatesNo longer taking part
- Northwestern UniversityChicago, United StatesNo longer taking part
- Biotech Clinical Research/ Georgia Vascular InstituteCollege Park, United StatesNo longer taking part
- The Ohio State UniversityColumbus, United StatesNo longer taking part
- Prostate Centers USAFalls Church, United StatesNo longer taking part
- Atlantic Medical ImagingGalloway, United StatesNo longer taking part
- Prostate Centers USALeesburg, United StatesNo longer taking part
- Memorial Care Long Beach Medical CenterLong Beach, United StatesNo longer taking part
- Northwell HealthManhasset, United StatesNo longer taking part
- Weill Cornell MedicineNew York, United StatesNo longer taking part
- Rutgers HealthNewark, United StatesNo longer taking part
- CardioVascular Health ClinicOklahoma City, United StatesNo longer taking part
- Prostate Centers USARaleigh, United StatesNo longer taking part
- Sunrise Vascular CenterSanford, United StatesNo longer taking part
- Saint Louis UniversitySt Louis, United StatesNo longer taking part
- Georgetown University Medical CenterWashington D.C., United StatesNo longer taking part
- MedStar Washington Hospital CenterWashington D.C., United StatesNo longer taking part
- Atlas InterventionalWilliamsville, United StatesNo longer taking part
About the trial
What the trial wants to find out
This multicenter, prospective, interventional trial is designed to assess the outcome of subjects with symptomatic knee osteoarthritis (OA) that are randomized to treatment with either genicular artery embolization (GAE) using Embosphere Microspheres or steroid injection over a period of 24 months.
The 2 groups in the trial
- Genicular artery embolization with Embosphere MicrospheresTreatment being tested
Device: Embosphere Microspheres Embolic Agent: Embosphere Microspheres
Treatment: Embosphere Microspheres
- Corticosteroid Injection of the kneeExisting treatment, for comparison
Drug: Corticosteroid injection
Treatment: Corticosteroid injection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Multicenter, PrOspective, Randomized, Controlled Trial Comparing GenIcular Artery EmbOlization Using Embosphere Microspheres to Corticosteroid iNjections for the Treatment of Symptomatic Knee Osteoarthritis: MOTION Study
- Record updated
- 24 October 2025