Breathing Support Device Tested in Amyotrophic Lateral Sclerosis
Tests a cough-assist breathing device in adults with amyotrophic lateral sclerosis.
Plain-language title generated from the registry record
Registry title: Breathing With Amyotrophic Lateral Sclerosis
Key facts
- Where
- Toulouse, FranceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT05819931, who can take part
Where in France
- SLA Center - Purpan University Hospital Toulouse, FRANCEToulouse, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Toulouse
- Trial code
- NCT05819931
- Record updated
- 12 May 2026
- Original description
The study aims to evaluate the effect of mechanical insufflator-exsufflator on the respiratory functions of Amyotrophic Lateral Sclerosis (ALS) patients evaluated via peak expiratory flow on cough (PEFC) measurements. The evolution of their PEFC is monitored to see if the curative management can have a positive impact on the latter.Read full original descriptionShow less
Evaluation of the Effect of Respiratory Physiotherapy by Mechanical In-exsufflator on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis: A Pilot Study
The study aims to evaluate the effect of mechanical insufflator-exsufflator on the respiratory functions of Amyotrophic Lateral Sclerosis (ALS) patients evaluated via peak expiratory flow on cough (PEFC) measurements. The evolution of their PEFC is monitored to see if the curative management can have a positive impact on the latter.
Inclusion: Confirmed ALS categorized as probable or certain according to the revised Awaji-Shima criteria [27]; ALS of spinal, bulbar or respiratory forms; Peak Flow measure between 160 and 255 L/min (recommendation of MIE in case of congestion, with the possibility of daily sessions); Patient who has not benefited from treatment by MIE in the past year (less than 10 sessions in total); Patient able to use the MIE and perform the collection, or having a caregiver able to help; Patient receiving physiotherapist treatment greater than or equal to twice a week.
Exclusion: Psychiatric (DSM-5) or cognitive disorders incompatible with participation in the study; Contraindication to the use of an MIE (pneumothorax for example); Insufficient level in French for understanding the study and completing the questionnaires; Current or past participation in another innovative research or care program relating to respiratory functions; Emergency situation for which the MIE must be set up within less than a week; Exclusion during the study :; Appearance of a serious contraindication to the practice of MIE during the study (for example rib fracture during a fall); Patient's physiotherapist refusing to do the study.