ALS (motor neurone disease) trials in France

In France 27 Also abroad 225

27 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Anticipated Patient and Caregiver Burden
Where
Marseille
Age
18 years and over
People
126
Run by
Assistance Publique Hopitaux De Marseille
See details and how to joinNCT05632757
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Where
Lille, Marseille, Nice, Paris, Tours
Age
18 years to 80 years
People
500 worldwide
Run by
Prilenia
See details and how to joinNCT07322003
No phaseTaking people
Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis Diagnosis
Where
Bordeaux, Clermont-Ferrand, Lyon, Marseille, Montpellier, Nîmes, Toulouse
Age
18 years and over
People
192
Run by
Centre Hospitalier Universitaire de Nīmes
See details and how to joinNCT06083584
Phase 2Taking people
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Where
Clermont Ferrand Cedex 1, Limoges Cedex 1, Montpellier Cedex 5, Nice, Paris, Tours Cedex 9
Age
18 years and over
People
240 worldwide
Run by
Zydus Therapeutics Inc.
See details and how to joinNCT07023835 · EU 2025-522580-15-00
Phase 1/2Taking people
Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic Lateral Sclerosis.
Where
Paris
Age
18 years to 80 years
People
23
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT07571486 · EU 2024-513471-40-00
No phaseTaking people
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
Where
Lille, Limoges, Marseille, Montpellier, Nice, Paris, Tours
Age
18 years and over
People
1,000 worldwide
Run by
University Hospital, Limoges
See details and how to joinNCT06147843
No phaseTaking people
QCT in ALS Diagnosis, Mechanistic Understanding and Follow-up
Where
Clermont-Ferrand
Age
18 years and over
People
30
Run by
University Hospital, Clermont-Ferrand
See details and how to joinNCT06284161
No phaseNot yet taking people in France
Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS Patients
Where
Montpellier
Age
18 years and over
People
200 worldwide
Run by
University Hospital, Montpellier
See details and how to joinNCT07737977
No phaseNot yet taking people in France
Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)
Where
Garches, Grenoble, Nîmes, Saint-Etienne
Age
18 years to 65 years
People
3
Run by
University Hospital, Grenoble
See details and how to joinNCT07698496
No phaseTaking people
Identification of Early Markers for ALS
Where
Tours
Age
18 years to 90 years
People
60
Run by
Institut National de la Santé Et de la Recherche Médicale, France
See details and how to joinNCT07213440
No phaseTaking people
Influence of Olfacto-gustatory Sensoriality on the Nutritional Status of Patients With Amyotrophic Lateral Sclerosis
Where
Dijon
Age
18 years and over
People
60
Run by
Centre Hospitalier Universitaire Dijon
See details and how to joinNCT06608004
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS (PREVAiLS)
Where
Lille Cedex, Marseille, Nice, Paris, Tours
Age
18 years and over
People
420 worldwide
Run by
Ferrer Internacional S.A.
See details and how to join2025-524002-16-00 · EU 2025-524002-16-00
No phaseTaking people
Breathing With Amyotrophic Lateral Sclerosis
Where
Toulouse
Age
18 years to 100 years
People
36
Run by
University Hospital, Toulouse
See details and how to joinNCT05819931
No phaseTaking people
Modeling Amyotrophic Lateral Sclerosis With Fibroblasts
Where
Paris
Age
18 years and over
People
110
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06450691
No phaseNot yet taking people in France
Characterization of Platelet Molecular Profiles in ALS for the Identification of Specific Diagnostic Biomarkers - A Pilot Study
Where
Limoges, Lyon, Tours
Age
18 years to 75 years
People
60
Run by
University Hospital, Tours
See details and how to joinNCT07479017
No phaseTaking people
Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments
Where
Paris
Age
18 years and over
People
180
Run by
Institut National de la Santé Et de la Recherche Médicale, France
See details and how to joinNCT04816227
No phaseTaking people
Alleviating Persistent Dyspnea in Amyotrophic Lateral Sclerosis Patients Treated With Non-Invasive Ventilation Through Immersive Virtual Reality
Where
Paris
Age
18 years and over
People
35
Run by
Assistance Publique - Hôpitaux de Paris
See details and how to joinNCT06021938
Phase 3Not yet taking people in France
Sustained-release oral morphine to alleviate persistent dyspnea in patients with chronic respiratory insufficiency due to amyotrophic lateral sclerosis outside the administration of ventilatory assistance: prospective multicenter randomized, placebo-controlled study, parallel arms (OPIDYS-ALS).
Where
Angers, Besancon Cedex, Dijon, Nancy, Paris, Toulouse
Age
18 years and over
People
160
Run by
Assistance Publique Hopitaux De Paris
See details and how to join2025-522546-52-00 · EU 2025-522546-52-00
No phaseTaking people
The Importance of Positive Expiratory Pressure Associated With the In-exsufflator in ALS Patients
Where
Le Havre
Age
18 years to 100 years
People
11
Run by
Groupe Hospitalier du Havre
See details and how to joinNCT06249412
No phaseTaking people
Interest of Measuring P2X4 Receptors on Blood Monocytes as a Diagnostic Marker in Amyotrophic Lateral Sclerosis: P2X4 as a Diagnostic Biomarker for ALS
Where
Bordeaux
Age
18 years and over
People
50
Run by
University Hospital, Bordeaux
See details and how to joinNCT07091799
No phaseTaking people
Control Cohort CTRL COH
Where
Bron
Age
18 years and over
People
350
Run by
Hospices Civils de Lyon
See details and how to joinNCT05370079
No phaseTaking people
Identifying Biomarkers in ALS Patients Using Neuronal Derived Extracellular Vesicles
Where
Paris
Age
18 years and over
People
60
Run by
Fondation Ophtalmologique Adolphe de Rothschild
See details and how to joinNCT07334743
Phase 3Not yet taking people in France
Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients
Where
Lille, Limoges, Ljubljana, Nice
Age
18 years to 80 years
People
412 worldwide
Run by
AB Science
See details and how to joinNCT07174492 · EU 2024-511244-12-01
No phaseTaking people
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
Where
Marseille
Age
18 years to 90 years
People
700
Run by
Assistance Publique Hopitaux De Marseille
See details and how to joinNCT07202494
Phase 3Taking people
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
Where
Angers, Bordeaux, Bron, Clermont-Ferrand, Lille, Limoges, Marseille, Montpellier, Nancy, Nice, Tours
Age
18 years to 81 years
People
495 worldwide
Run by
AB Science
See details and how to joinNCT03127267