Tests a smoking quit program for people with HIV or TB in South Africa
Tests a combined smoking quit program in adults with HIV or tuberculosis.
Plain-language title generated from the registry record
Registry title: South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Key facts
- Where
- Rondebosch, South AfricaSee the site
Where in South Africa
- University of Cape TownRondebosch, South AfricaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts General Hospital
- Trial code
- NCT05842161
- Record updated
- 9 September 2026
- Original description
The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.Read full original descriptionShow less
Treatment Development for Smoking Cessation and Engagement in HIV/TB
The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.
Inclusion: Aged 18 or older; Willing and able to provide written informed consent; Living with HIV, confirmed via medical record, and history of taking ART for at least three months (consecutively or non-consecutively); Within 4 months of initiating or reinitiating TB treatment; positive GeneXpert test or sputum culture; Habitual smoker operationalized as smoking at least 4 days a week; Motivation (> 5/10) to quit smoking or > 24 hour quit past yr; Must be living in the catchment area for either the Town Two Clinic or the Michael Mapongwana Community Health Clinic in Khayelitsha.
Exclusion: Cognitive Behavioral Therapy for smoking cessation initiated within the past year,; Diagnosed with extra-pulmonary or drug resistant (MDR or XDR) TB based upon chart review; Current interfering untreated/unstable mental health condition (e.g., psychosis, bipolar dx); Current use of non-study pharmacotherapy for smoking cessation,.