HIV trials in South Africa

In South Africa 57 Also abroad 789

57 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Integrating U=U Into HIV Counseling in South Africa (INTUIT-2.0)
Where
Johannesburg
Age
18 years and over
People
880
Run by
Boston University
See details and how to joinNCT07199634
Phase 4Taking people
A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
Where
Cape Town, Durban, Johannesburg, Paarl, Pretoria, Soweto
Age
1 month and over
People
350 worldwide
Run by
Gilead Sciences
See details and how to joinNCT06337032
No phaseTaking people
Evaluating the Impact of Using the B-OK Bottles for HIV and ART Literacy in South Africa
Where
Johannesburg
Age
18 years and over
People
600
Run by
University of Pennsylvania
See details and how to joinNCT07703891
Phase 2/3Taking people
A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)
Where
Bloemfontein, Durban, Mbekweni, Paarl
Age
18 years and over
People
570 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07266831 · EU 2025-522519-40-00
No phaseTaking people
Feasibility Study Comparing One vs Two Probes for Thermal Ablation Among Cervical Cancer Screen Positive WLWH in C1001P-CS9 South Africa
Where
Durban
Age
25 years to 49 years
People
200
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT07645378
Phase 2Taking people
Evaluating the Safety and Immunogenicity of MTBVAC
Where
Cape Town, Chatsworth, Durban, Isipingo, Johannesburg, Klerksdorp, Ladysmith, Rustenburg, Soshanguve, Westdene, Worcester
Age
12 years to 55 years
People
276
Run by
HIV Vaccine Trials Network
See details and how to joinNCT05947890
Phase 2Taking people
Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)
Where
Bloemfontein, Cape Town, Durban, Johannesburg, Paarl, Plettenberg Bay
Age
4 weeks to 11 years
People
84 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT04375800
No phaseTaking people
Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment
Where
East London, Pietermaritzburg, Port Elizabeth, Port Shepstone
Age
18 years and over
People
2,944
Run by
Johns Hopkins University
See details and how to joinNCT05671718
No phaseTaking people
Healer-initiated HIV Counseling and Testing Versus Standard of Care in Rural South Africa
Where
Agincourt
Age
18 years and over
People
230,907
Run by
Vanderbilt University Medical Center
See details and how to joinNCT06483854
Phase 3Taking people
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Where
Bloemfontein, Cape Town, Chatsworth, Durban, East London, Edendale, Johannesburg, Johnnesburg, Khayelitsha, Ladysmith, Ndevana, Phoenix, Pietermaritzburg, Pretoria, Somkhele - Mtubatuba, Verulam
Age
16 years to 30 years
People
4,580 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07071623
Phase 2/3Taking people
Evaluating Smoking Cessation Interventions for PWH in South Africa
Where
Soweto
Age
18 years and over
People
660
Run by
Johns Hopkins University
See details and how to joinNCT05413122
Phase 1Taking people
A Clinical Trial to Look at the Safety and Immune Responses of the RNA-based Vaccine BNT168 in Adults Living With or Without HIV
Where
Johannesburg
Age
18 years to 50 years
People
126 worldwide
Run by
BioNTech SE
See details and how to joinNCT07698600
No phaseTaking people
A Study to Evaluate Performance, Usability, and Contrived Result Interpretation of TruPlex HIV/HepB/Syphilis Rapid Test
Where
Cape Town, Durban, Johannesburg
Age
18 years and over
People
1,000
Run by
bioLytical Laboratories
See details and how to joinNCT07563309
No phaseTaking people
Urine HPV Testing for Cervical Cancer Screening Among Women Living With HIV in South Africa
Where
Westdene
Age
25 years and over
People
300
Run by
UNC Lineberger Comprehensive Cancer Center
See details and how to joinNCT05413798
No phaseTaking people
Implementing Depression and Adherence Treatment
Where
Cape Town
Age
18 years and over
People
10
Run by
University of Miami
See details and how to joinNCT07032363
Phase 1Not yet taking people in South Africa
Safety & Immunogenicity of 426c.Mod.Core-C4b Vaccine With 3M-052-AF+Alum in Infants Perinatally Exposed to HIV But Uninfected
Where
Soweto
Age
Up to 7 days
People
22
Run by
HIV Vaccine Trials Network
See details and how to joinNCT06613789
Phase 1/2Taking people
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
Where
Durban, Johannesburg, Tygerberg
Age
Up to 48 hours
People
1,120 worldwide
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT02140255
No phaseTaking people
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Where
Rondebosch
Age
18 years and over
People
83
Run by
Massachusetts General Hospital
See details and how to joinNCT05842161
No phaseNot yet taking people in South Africa
Intervention Development for Syndemics Among PWH in SA
Where
Cape Town
Age
18 years and over
People
60
Run by
Massachusetts General Hospital
See details and how to joinNCT06152003
Phase 3Taking people
A Continued Access Study for Participants Transitioning From ViiV Healthcare-sponsored or ViiV Healthcare-collaborative Parent Studies for HIV Treatment
Where
Durban, Gauteng, Johannesburg, Jouberton
People
181
Run by
ViiV Healthcare
See details and how to joinNCT07393659
No phaseNot yet taking people in South Africa
Community Popular Opinion Leader Intervention for HIV Prevention Uptake in Rural South Africa
Where
uMkhanyakude
Age
18 years to 28 years
People
60
Run by
Africa Health Research Institute
See details and how to joinNCT07741474
No phaseTaking people
HomeLink2: Reducing Posthospitalization Mortality Through Structured Home Care and Nutritional Support
Where
Klerksdorp
Age
18 years and over
People
780
Run by
Johns Hopkins University
See details and how to joinNCT07102745
No phaseTaking people
Reducing Psychological Barriers to PrEP Persistence Among Pregnant and Postpartum Women in Cape Town, South Africa
Where
Cape Town
Age
15 years and over
People
118 worldwide
Run by
Boston University Charles River Campus
See details and how to joinNCT05624931
Phase 3Taking people
Long-Acting HIV Pre-Exposure Prophylaxis Integrated With Sexual and Reproductive Health - cRCT
Where
Somkele
Age
15 years to 30 years
People
2,052
Run by
Africa Health Research Institute
See details and how to joinNCT06250504
No phaseTaking people
Mentor Moms+ Study
Where
Cape Town, Saldanha Bay
Age
16 years and over
People
100
Run by
University of California, Los Angeles
See details and how to joinNCT06962592