Tests time-restricted eating in adults with obesity and prediabetes
Tests eating only within a 9 h window daily in adults with obesity or prediabetes.
Plain-language title generated from the registry record
Registry title: The Effect of Time-Restricted Eating in Cardiometabolic Health
Key facts
- Where
- Cambridge, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 75 years old?
Source: NCT05866406, who can take part
Where in United Kingdom
- Cambridge Clinical Research CenterCambridge, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cambridge University Hospitals NHS Foundation Trust
- Trial code
- NCT05866406
- Record updated
- 28 May 2026
- Original description
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.Read full original descriptionShow less
The Effect of Time-Restricted Eating in Cardiometabolic Health
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no energy intake the rest of the day. In rodents, TRE improves metabolic function without caloric restriction, potentially by activating nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on cardiometabolic health in people is not clear and few studies have evaluated this issue. Accordingly, the investigators propose to conduct a randomized controlled trial in people with obesity and prediabetes to determine the effect of 9 h TRE for 12 weeks, without a change in body weight, on key metabolic outcomes that are risk factors for cardiovascular disease (CVD): 1) multi-organ insulin sensitivity; 2) 24 h metabolic homeostasis and diurnal rhythm; and 3) adipose tissue and skeletal muscle biology. The proposed studies will elucidate the cardiometabolic implications of TRE in people with obesity and prediabetes.
Inclusion: must be able to grant voluntary informed consent and comply with the study instructions; aged 25-75 years; men and women; body mass index 27-45 kg/m2; fasting plasma glucose 5.6-6.9 mmol/L, or 2h oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol or homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73; self-reported habitual eating period ≥ 13 h per day.
Exclusion: use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha- or beta-adrenergic blockers or agonists, etc.); smoking and illegal drug use; gastrointestinal or bariatric surgery (except cholecystectomy and appendectomy); Clinical diagnosis of type 1 or 2 diabetes; Clinical diagnosis of sleep disorder; Clinical diagnosis of eating disorder; Clinical diagnosis of cancer in last 5 years; conditions that render subject unable to complete all testing procedures (including individuals with known allergies or contraindications to the medications used in this study); shift worker; fasting >12 h/day more than once a week; vegan; > once a week no food intake after ~1800 h; habitually waking up before ~0400 h and sleeping before ~2100 h; unstable weight (>5% change the last 2 months); pregnant or lactating; individuals with electromedical devises; prisoners; alcohol abuse.