Tests weight loss against weight stability in older Veterans with obesity and long COVID
Tests a weight loss program in Veterans with obesity and long COVID.
Plain-language title generated from the registry record
Registry title: Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
Key facts
- Where
- Baltimore and San Antonio, United StatesSee the 2 sites
Where in United States
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MDBaltimore, United StatesTaking people
- South Texas Health Care System, San Antonio, TXSan Antonio, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT05880108
- Record updated
- 1 June 2026
- Original description
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.Read full original descriptionShow less
Modifying Adiposity Through Behavioral Strategies to Improve COVID-19 Rehabilitation
The research in this VA Merit will examine the effects of obesity and Post-COVID Conditions (PCC) on physical functioning, health-related quality of life, and adipose tissue inflammatory and cellular senescence profiles in older Veterans. Further, it will evaluate whether a weight loss intervention, including dietary modification and exercise, in obese Veterans with and without PCC will reduce systemic and adipose tissue inflammation and senescence and promote PCC recovery.
Inclusion: U.S. Veteran; Self-reported COVID-19 naïve or COVID-19 > 90 days ago for lean and obese PCC naïve or documented COVID-19 for the lean and obese PCC groups (At least one PCC symptom >4 weeks); Body Mass Index: 19-25 or 30-50 kg/m2.
Exclusion: Self-reported alcohol or drug abuse; Anti-coagulant medication usage; Neurologic, musculoskeletal, or other condition that limits subject's ability to complete study physical assessments; Active inflammatory, COVID-19, autoimmune, infectious, hepatic (LFTs > 2.5 x WNL), renal (eGFR<45), gastrointestinal, malignant, and psychiatric disease; Uncontrolled diabetes (HbA1c >10% or the current use of insulin); Weight change within the past month of >5 kg.