Long COVID and ME/CFS trials in United States

In United States 68 Also abroad 176

68 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2Enrolling by invitation
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2
Where
Bethesda
Age
18 years to 100 years
People
45
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT05350774
Phase 1Not yet taking people in United States
Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)
Where
Bethesda
Age
18 years to 110 years
People
15
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT07388550
Phase 3Not yet taking people in United States
The Study of Brave-LC LDN Treatment Trial
Where
Baltimore, Birmingham, Boston, Brooklyn, Chicago, Chula Vista, Denver, Gainesville, Houston, Lebanon, New Brunswick, New York, Worcester
Age
6 years to 25 years
People
1,300
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT07916259
No phaseTaking people
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
Where
Birmingham
Age
18 years and over
People
30
Run by
University of Alabama at Birmingham
See details and how to joinNCT07523113
Phase 2Taking people
SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
Where
New York
Age
18 years to 65 years
People
150
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07597902
No phaseEnrolling by invitation
Fareon Open Label Device Clinical Trial
Where
New York
Age
16 years and over
People
30
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07600320
Phase 2Taking people
LIFT: Life Improvement Trial
Where
Boston
Age
18 years to 70 years
People
160
Run by
Brigham and Women's Hospital
See details and how to joinNCT06366724
Phase 2Not yet taking people in United States
Low-Dose Naltrexone For ME/CFS: Dose-Finding
Where
Birmingham
Age
18 years to 65 years
People
75
Run by
University of Alabama at Birmingham
See details and how to joinNCT07285473
Phase 3Taking people
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
Where
San Diego
Age
18 years to 65 years
People
348 worldwide
Run by
Douglas D. Fraser
See details and how to joinNCT06928272
No phaseNot yet taking people in United States
The Precision Mito- Mito Map COMPASS Study
Where
Fort Myers
Age
18 years and over
People
400
Run by
AI Agent Vault, Inc. d/b/a Precision Mito
See details and how to joinNCT07856121
Phase 2Taking people
SARS-CoV-2 Specific Monoclonal Antibody for Post-COVID-19 Conditions (Long COVID)
Where
Fort Lauderdale
Age
18 years to 70 years
People
100
Run by
Nancy Klimas
See details and how to joinNCT07021794
No phaseTaking people
Heat thErapy And mobiLity in COVID-19 Survivors
Where
Omaha
Age
50 years to 90 years
People
99
Run by
University of Nebraska
See details and how to joinNCT06928116
No phaseTaking people
Long-Term Study of COVID-19 Infection and Long COVID
Where
Chapel Hill
Age
18 years to 75 years
People
500
Run by
University of North Carolina, Chapel Hill
See details and how to joinNCT07781501
Phase 3Taking people
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
Where
Atlanta, Aurora, Boston, Brooklyn, Chicago, Cleveland, Gainesville, Los Angeles, Minneapolis, Morgantown, Nashville, New Haven, San Antonio, San Francisco, Seattle, Tucson
Age
18 years and over
People
550
Run by
Wes Ely
See details and how to joinNCT06631287
Phase 2Taking people
A Study to Examine Anktiva for the Treatment of COVID-19.
Where
El Segundo
Age
18 years to 70 years
People
40
Run by
ImmunityBio, Inc.
See details and how to joinNCT07123727
No phaseTaking people
Cross-Sectional Evaluation of Persistence of SARS-CoV-2 Remnants After Recovery From Acute Infection
Where
Bethesda
Age
18 years to 110 years
People
12
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT06577467
No phaseTaking people
Long-Covid-19 Alleviation Through Learning Mindfulness Study
Where
New York
Age
18 years and over
People
400
Run by
Columbia University
See details and how to joinNCT07140094
No phaseTaking people
Post COVID-19 Syndrome Treatment With Variable Pulse Transcranial Magnetic Stimulation
Where
Rochester
Age
18 years to 65 years
People
40
Run by
Mayo Clinic
See details and how to joinNCT06865222
Phase 1Taking people
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Where
Bethesda
Age
18 years to 70 years
People
60
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT06920628
No phaseTaking people
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
Where
San Francisco
Age
18 years and over
People
150
Run by
University of California, San Francisco
See details and how to joinNCT07770022
No phaseTaking people
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Where
Stony Brook
Age
18 years to 65 years
People
80
Run by
Fred Friedberg
See details and how to joinNCT07753122
No phaseTaking people
Long-term COVID and Rehabilitation
Where
Salt Lake City
Age
18 years and over
People
300
Run by
VA Office of Research and Development
See details and how to joinNCT05373043
No phaseTaking people
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
Where
San Francisco
Age
18 years to 100 years
People
800
Run by
University of California, San Francisco
See details and how to joinNCT04362150
No phaseEnrolling by invitation
Cognitive Rehabilitation Therapy for COVID-19
Where
San Diego
Age
18 years and over
People
70
Run by
VA Office of Research and Development
See details and how to joinNCT06086379
Phase 2Taking people
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
Where
Albuquerque
Age
18 years to 80 years
People
60
Run by
University of New Mexico
See details and how to joinNCT06940609