Checks how sulthiame affects brain wave recordings in children with epilepsy
Studies sulthiame in children aged 6 to 15 with epilepsy, using sleep brain wave recordings.
Plain-language title generated from the registry record
Registry title: Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
Key facts
- Where
- Angers, Strasbourg, and Toulouse, FranceSee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 6 and 15 years old?
Source: NCT05885646, who can take part
Where in France
- Angers University Hospital, Pediatric departmentAngers, FranceTaking people
- Strasbourg University Hospital, Pediatric departmentStrasbourg, FranceNot yet recruiting
- Toulouse University Hospital, Pediatric Neurology DepartmentToulouse, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Angers
- Trial code
- NCT05885646
- Record updated
- 15 June 2025
- Original description
The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.Read full original descriptionShow less
Treatment of Epilepsy Syndromes of Childhood With Sleep Activation Using Sulthiame: an Exploratory Study of the Short Term Effect on EEG
The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.
Inclusion: Diagnosis of epilepsy syndromes of childhood with sleep activation; Failure of at least two anti-epileptic drugs (AED); Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG).
Exclusion: Previous trial with sulthiame; Use of corticosteroids at inclusion; Change in the anti-epileptic treatment in the 7 days before baseline EEG; More than 2 AED at inclusion.