BAriatric Surgery Induced Chromosomal Change
Reason given: Issue with telomere measurement
Key facts
- Where
- Weston, United StatesSee the site
Where in United States
- Cleveland Clinic FloridaWeston, United StatesNo longer taking part
Trial details
- Who runs it
- The Cleveland Clinic
- Trial code
- NCT05903521
- Record updated
- 24 October 2025
- Original description
The purpose of this study is to better understand the impact of weight-loss surgery on telomere length. Telomeres are a key marker of biological aging of cells. Telomere shortening is a natural process of aging. Several pathologies and lifestyles are associated with premature telomere shortening, such as obesity, diabetes mellitus or sedentary lifestyle. New evidence supports that telomere shortening can be partially reversed by lifestyle changes such as healthy diet, reduced stress, or increased physical activity.Read full original descriptionShow less
Long-term Impact of Surgically Induced Rapid Weight Loss on Telomere Length and Its Potential Implications in the Genesis and Prevention of Neoplastic Disease Processes in Subjects With Severe Obesity
The purpose of this study is to better understand the impact of weight-loss surgery on telomere length. Telomeres are a key marker of biological aging of cells. Telomere shortening is a natural process of aging. Several pathologies and lifestyles are associated with premature telomere shortening, such as obesity, diabetes mellitus or sedentary lifestyle. New evidence supports that telomere shortening can be partially reversed by lifestyle changes such as healthy diet, reduced stress, or increased physical activity.
Inclusion: BMI ≥ 35 kg/m2 without previous bariatric surgery (control group) OR; Having had Sleeve Gastrectomy or Roux-en-Y Gastric Bypass more than 12 months ago and without a weight regain of ≥ 15% of nadir weight (treatment group).
Exclusion: under 18 years of age; no informed consent.