Studies how electroconvulsive therapy affects sleep and brain activity in depression
Studies how electroconvulsive therapy affects sleep and brain networks in treatment-resistant depression.
Plain-language title generated from the registry record
Registry title: Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Key facts
- Where
- St Louis, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 21 and 65 years old?
Source: NCT05905705, who can take part
Where in United States
- Washington University School of Medicine/Barnes-Jewish HospitalSt Louis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Washington University School of Medicine
- Trial code
- NCT05905705
- Record updated
- 12 March 2026
- Original description
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.Read full original descriptionShow less
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Inclusion: Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
Exclusion: Diagnoses of schizophrenia or schizoaffective disorders; Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.