Taking people in United StatesPhase 2
Study of ALTO-300 in MDD
Key facts
- Where
- Albuquerque, Allentown, Austin, Bellflower, Blackfoot, Boise, Carlsbad, Chicago, Cincinnati, Clermont, Clinton, Colorado Springs, Conroe, Creve Couer, Dallas, Denver, Evergreen, Fairfax, Fayetteville, Fort Worth, Glendale, Hattiesburg, Hickory, Houston, Jackson, Lafayette, Las Vegas, Los Angeles, Mankato, Marrero, Mather, Media, Miami Gardens, Miami Lakes, Minneapolis, Mission Viejo, Missouri City, Monroe, Moorpark, Moosic, New York, Norwalk, Okeechobee, Oklahoma City, Omaha, Phoenix, Plano, Provo, Richmond, Roanoke, Rochester, Rogers, Rose Hill, San Marcos, Savannah, Snellville, St Louis, Staten Island, Stephenville, Stone Mountain, Tampa, Temecula, West Palm Beach, Wichita, Winston-Salem, Worcester, and Yuma, United StatesSee the 74 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT05922878, who can take part
Where in United States
- AlbuquerqueAlbuquerque, United StatesTaking people
- AllentownAllentown, United StatesNo longer taking part
- AustinAustin, United StatesTaking people
- BellflowerBellflower, United StatesTaking people
- BlackfootBlackfoot, United StatesNo longer taking part
- BoiseBoise, United StatesTaking people
- BoiseBoise, United StatesNo longer taking part
- CarlsbadCarlsbad, United StatesNo longer taking part
- ChicagoChicago, United StatesNo longer taking part
- CincinnatiCincinnati, United StatesTaking people
- ClermontClermont, United StatesNo longer taking part
- ClintonClinton, United StatesNo longer taking part
- Colorado SpringsColorado Springs, United StatesNo longer taking part
- ConroeConroe, United StatesTaking people
- Creve CouerCreve Couer, United StatesNo longer taking part
- DallasDallas, United StatesNo longer taking part
- DenverDenver, United StatesTaking people
- EvergreenEvergreen, United StatesNo longer taking part
- EvergreenEvergreen, United StatesNo longer taking part
- FairfaxFairfax, United StatesTaking people
- FayettevilleFayetteville, United StatesTaking people
- Fort WorthFort Worth, United StatesNo longer taking part
- Fort WorthFort Worth, United StatesNo longer taking part
- GlendaleGlendale, United StatesNo longer taking part
- HattiesburgHattiesburg, United StatesNo longer taking part
- HickoryHickory, United StatesNo longer taking part
- HoustonHouston, United StatesTaking people
- HoustonHouston, United StatesTaking people
- JacksonJackson, United StatesNo longer taking part
- LafayetteLafayette, United StatesTaking people
- Las VegasLas Vegas, United StatesTaking people
- Los AngelesLos Angeles, United StatesNo longer taking part
- MankatoMankato, United StatesTaking people
- MarreroMarrero, United StatesNo longer taking part
- MatherMather, United StatesTaking people
- MediaMedia, United StatesNo longer taking part
- Miami GardensMiami Gardens, United StatesNo longer taking part
- Miami LakesMiami Lakes, United StatesNo longer taking part
- MinneapolisMinneapolis, United StatesTaking people
- Mission ViejoMission Viejo, United StatesNo longer taking part
- Missouri CityMissouri City, United StatesNo longer taking part
- MonroeMonroe, United StatesNo longer taking part
- MoorparkMoorpark, United StatesTaking people
- MoosicMoosic, United StatesNo longer taking part
- New YorkNew York, United StatesTaking people
- New YorkNew York, United StatesNo longer taking part
- NorwalkNorwalk, United StatesNo longer taking part
- OkeechobeeOkeechobee, United StatesNo longer taking part
- Oklahoma CityOklahoma City, United StatesNo longer taking part
- Oklahoma CityOklahoma City, United StatesNo longer taking part
- OmahaOmaha, United StatesNo longer taking part
- PhoenixPhoenix, United StatesTaking people
- PhoenixPhoenix, United StatesNo longer taking part
- PlanoPlano, United StatesTaking people
- ProvoProvo, United StatesNo longer taking part
- RichmondRichmond, United StatesNo longer taking part
- RoanokeRoanoke, United StatesNo longer taking part
- RochesterRochester, United StatesNo longer taking part
- RogersRogers, United StatesTaking people
- Rose HillRose Hill, United StatesTaking people
- San MarcosSan Marcos, United StatesTaking people
- SavannahSavannah, United StatesNo longer taking part
- SnellvilleSnellville, United StatesNo longer taking part
- St LouisSt Louis, United StatesTaking people
- Staten IslandStaten Island, United StatesNo longer taking part
- StephenvilleStephenville, United StatesTaking people
- Stone MountainStone Mountain, United StatesNot yet recruiting
- TampaTampa, United StatesTaking people
- TemeculaTemecula, United StatesTaking people
- West Palm BeachWest Palm Beach, United StatesNo longer taking part
- WichitaWichita, United StatesNo longer taking part
- Winston-SalemWinston-Salem, United StatesTaking people
- WorcesterWorcester, United StatesTaking people
- YumaYuma, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alto Neuroscience
- Trial code
- NCT05922878
- Record updated
- 26 October 2026
- Original description
The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics.Read full original descriptionShow less
A Randomized, Double-Blind, Placebo-Controlled Study of ALTO-300 With an Open-Label Extension in Adults With Major Depressive Disorder
The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics.
Inclusion: Have a diagnosis of moderate to severe major depressive disorder (MDD); At Visit 1, currently taking a stable dose of 1 or 2 antidepressants (e.g., SSRI, SNRI, bupropion, or gepirone) for at least 6 weeks with no dose modifications in the past 2 weeks by Visit 2; Willing to comply with all study assessments and procedures; Must not be pregnant or breastfeeding at time of enrollment or throughout study.
Exclusion: Nightly use of sleep medication; Concurrent or recent participation in another clinical trial for mental illness involving an investigational product or device; Evidence of unstable medical condition; Diagnosed bipolar disorder, psychotic disorder, or dementia; Current moderate or severe substance use disorder; Has a history of hypersensitivity or allergic reaction to ALTO-300 or any of its components/excipients.