Studies fat tissue changes and diabetes remission after weight-loss surgery
Tests whether fat tissue changes explain diabetes remission in adults after bariatric surgery.
Plain-language title generated from the registry record
Registry title: Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
Key facts
- Where
- Sherbrooke, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05934409, who can take part
Where in Canada
- Centre de recherche du CHUSSherbrooke, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Université de Sherbrooke
- Trial code
- NCT05934409
- Record updated
- 10 February 2026
- Original description
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.Read full original descriptionShow less
Improved Adipose Tissue Storage of Dietary Fatty Acids as a New Mechanism for the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery
The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery.
All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.
Inclusion: Aged 18 to 65; BMI 35 kg/m2; Diagnosed T2D - according to Diabetes Canada diagnostics criteria; Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria; Women with a negative serum pregnancy test.
Exclusion: Treatment with an oral contraceptive; Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects; Having participated to a research study with exposure to radiation in the last two years before the start of the study; Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions; Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension; A Diabetes Remission (DiaRem) score >8 (low probability of T2D remission); Being allergic to eggs; Smoking or consumption of more than 2 alcoholic beverages per day; Any contraindication to MRI; Pregnant or breastfeeding women; Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET/CT scanners.