Brain-based tools to find Veterans with psychosis who may benefit from cognitive rehabilitation

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a long-lasting psychotic disorder such as schizophrenia, and also for healthy adults as comparison volunteers. It tests brain-based measures linked to cognitive rehabilitation.

Age

18 Years to 75 Years

Sex

All sexes can join.

Disease stage

A chronic psychotic disorder (for example schizophrenia, schizoaffective disorder or delusional disorder) by DSM-5 diagnosis, or good general mental and physical health with no active mental health condition.

Main reasons for not taking part

• Active use of a substance other than cannabis within the last 30 days
• History of significant medical or neurological illness or intellectual disability
• Cannot understand or give informed consent
• Healthy comparison volunteers: past or present schizophrenia, schizoaffective disorder or other chronic psychotic disorder
• Not fluent in spoken and written English, or impaired hearing or vision

The registry criteria, word for word

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

• Are you between 18 and 75 years old?YesNo

What the trial wants to find out

Cognitive symptoms of schizophrenia interfere with daily life-from managing self-care, to more complex tasks like taking medications and living independently. Unfortunately, these cognitive symptoms are not corrected by 'standard of care' treatments (antipsychotic medications), although some schizophrenia patients may experience modest clinical and cognitive benefits from cognitive remediation. To enhance the clinical impact of cognitive remediation and other rehabilitative interventions for Veterans living with chronic psychosis, this study will develop novel brain-based tools to help identify those Veterans who are most likely to benefit from pro-cognitive therapies. These studies may advance predictive algorithms that improve functional outcomes and life quality in Veterans with schizophrenia.

The 3 groups in the trial

• Biomarker Optimization - Patients

  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System who have a diagnosis of a chronic psychotic disorder (e.g., schizophrenia or schizoaffective disorder).

  Treatment: Neurophysiologic Biomarker Assessments

• Biomarker Optimization - Healthy Comparison Subjects

  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System who have no history of mental illness.

  Treatment: Neurophysiologic Biomarker Assessments

• Biomarker Validation in Chronic Psychotic Disorders

  Veterans currently enrolled for healthcare services at the VA San Diego Healthcare System with a diagnosis of a chronic psychotic disorder (e.g., schizophrenia or schizoaffective disorder).

  Treatment: Neurophysiologic Biomarker Assessments