Gut Bacteria and Infections in Adults with Obesity or Type 2 Diabetes
Compares gut bacteria in adults with obesity or diabetes who have chronic infections.
Plain-language title generated from the registry record
Registry title: Susceptibility to Infectious Diseases in Obesity
Key facts
- Where
- Novara, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05975541, who can take part
Where in Italy
- Maggiore della Carità HospitalNovara, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Azienda Ospedaliero Universitaria Maggiore della Carita
- Trial code
- NCT05975541
- Record updated
- 10 September 2026
- Original description
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology". The gut microbiota is strictly interconnected with obesity and T2D playing also an important role in immune system regulation.Read full original descriptionShow less
Susceptibility to Infectious Diseases in Obesity: an Endocrine, Translational, Sociological Evaluation
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology". The gut microbiota is strictly interconnected with obesity and T2D playing also an important role in immune system regulation.
Obesity and diabetes can lead to chronic inflammation, which results in the secretion of pro-inflammatory cytokines like IL-6, IL-1, and TNF-alpha, causing immune system alteration which predisposes patients with obesity and T2D to chronic infections. Therefore, the principal aim of the study is to investigate changes in gut microbiota composition between patients with chronic infections or not, so as to attribute to specific phyla the formation of the infections in these patients.
Inclusion: age between 18-65 years; ability to understand the study protocol; obesity with BMI between 30-40 kg/m2; affects by type II diabetes; presence/absence of chronic infections; the possibility of equality in the two groups (matched for sex, age, and therapies).
Exclusion: bariatric surgery; Alcohol or drug abuse; antibiotic therapy; psychological conditions that reduced the ability the comprehension of the study protocol; patients with relapsing infections; subjects undergoing a diet-therapeutic regimen; subjects with the possibility of developing diabetic foot in the successive months; pregnancy; oncological and hematological pathologies; Hypogonadism; severe immunodepression; vaccination in the last two weeks.