Studying brain responses to repeated magnetic stimulation in depression and epilepsy
Tests repeated magnetic brain stimulation in adults with depression or epilepsy, measuring brain activity.
Plain-language title generated from the registry record
Registry title: Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Key facts
- Where
- Stanford, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT05996900, who can take part
Where in United States
- Stanford UniversityStanford, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Stanford University
- Trial code
- NCT05996900
- Record updated
- 12 March 2026
- Original description
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.Read full original descriptionShow less
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.
Inclusion: Men and women, ages 18 to 65; Medication-refractory epilepsy requiring phase II monitoring; Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent; No current or history of major neurological disorders other than epilepsy.
Exclusion: Any unstable medical condition; Neurological or uncontrolled medical disease; Those with a contraindication for MRIs (e.g. implanted metal); Active substance abuse; Currently pregnant or breastfeeding.