Tests oral dexamethasone added to nerve block for migraine headache
Tests whether oral dexamethasone added to a nerve block helps adults with migraine.
Plain-language title generated from the registry record
Registry title: Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?
Key facts
- Where
- El Paso, United StatesSee the site
- Phase
- Early phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06016465, who can take part
Where in United States
- University Medical Center of El PasoEl Paso, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Texas Tech University Health Sciences Center, El Paso
- Trial code
- NCT06016465
- Record updated
- 6 May 2026
- Original description
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.Read full original descriptionShow less
Does Nerve Block Plus Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hours Better Than Nerve Block Alone?
For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.
Inclusion: Meet ICHD-3 Migraine Headache Criteria; Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2; Nerve block performed with bupivacaine 0.5%.
Exclusion: Chronically on steroids; Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma); Headache in the setting of viral syndrome; Known allergy to dexamethasone; Gestational diabetes or other uncontrolled diabetes; Head trauma; Unable to reach the patient by phone or text for follow-up; Known to be immunocompromised.