Collecting Blood and Brain Tissue to Study Drug-Resistant Epilepsy
Collects blood and brain tissue from adults having surgery for drug-resistant focal epilepsy.
Key facts
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Where
- Paris, FranceSee the site
- Trial code
- Registry title
- Multimodal Study of the Human Brain Epilepsy Tissue
- Status
- Recruiting
- People taking part
- 300 people, planned
- Started
- 29 Feb 2024
- Expected to end
- 28 Feb 2037
- Type of study
- Interventional
- Treatments tested
- Blood and tissue collection
- Record updated
- 16 July 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with focal drug-resistant epilepsy who are in hospital for a pre-surgical evaluation or for epilepsy surgery. Blood and brain tissue samples are collected for research.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Focal epilepsy that does not respond to drugs (drug-resistant).
Main reasons for not taking part
- The record lists no exclusion criteria.
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- 18 yo or above
- patients with a focal drug-resistant epilepsy
- patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery
- consent obtained from the patient, or legally authorized representative
- affiliated to a social security system
Who cannot take part
- None
Where in France
- Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière HospitalParis, FranceContact: Vincent M. Navarro, MD, PHDTaking people
About the trial
What the trial wants to find out
The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy.
Read full original descriptionShow less
The aim of the study will be to identify new pathophysiological pathways. For this purpose, the investigators will investigate with a multimodal approach blood and brain samples from patients undergoing a surgery for focal drug-resistant epilepsy. The adult patients will be enrolled either during the pre-surgical evaluation or right before the surgery.
The group in the trial
- epileptic patientsTreatment being tested
All patients will be enrolled in the same arm. Patients can be enrolled during the pre-surgical evaluation (group 1) or in the days preceding the surgery (group 2).
Treatment: Blood and tissue collection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Multimodal Study of the Human Brain Epilepsy Tissue
- Plain-language title
- Collecting Blood and Brain Tissue to Study Drug-Resistant EpilepsyGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 16 July 2026