Taking people in United StatesNo phase

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

Key facts

Where: Albuquerque, Asheville, Atlanta, Atlantis, Austin, Baltimore, Bloomington, Boise, Boston, Camden, Celebration, Charleston, Charlotte, Chicago, Cincinnati, Clearwater, Columbus, Crystal River, Dallas, Denver, Detroit, Doylestown, Gainesville, Germantown, Glendale, Golden, Hackensack, Hollywood, Jacksonville, Kansas City, Lancaster, Lansing, Lexington, Loveland, Lynchburg, Marietta, Marlton, Miami, Miami Beach, Milwaukee, Minneapolis, Morgantown, Nashville, Neptune City, New Hyde Park, New Orleans, New York, Newport Beach, Oklahoma City, Philadelphia, Raleigh, Redwood City, Ridgewood, Rochester, San Diego, San Francisco, Sarasota, Scottsdale, St Louis, Washington D.C., Wichita, and Ypsilanti, United StatesSee the 72 sites

Where in United States

Lovelace Medical Center (New Mexico Heart Institute)Albuquerque, United StatesNo longer taking part
HCA Asheville Cardiology AssociatesAsheville, United StatesTaking people
Piedmont Healthcare, IncAtlanta, United StatesNo longer taking part
HCA Florida JFK HospitalAtlantis, United StatesNo longer taking part
Ascension SetonAustin, United StatesNo longer taking part
The Johns Hopkins UniversityBaltimore, United StatesTaking people
MedStar Union Memorial HospitalBaltimore, United StatesNo longer taking part
Health Partners Institute (Methodist Heart and Vascular Center)Bloomington, United StatesNo longer taking part
St. Luke's Idaho CardiologyBoise, United StatesNo longer taking part
St. Elizabeth's Medical CenterBoston, United StatesTaking people
Beth Israel Deaconess Medical CenterBoston, United StatesNo longer taking part
The Brigham and Women's HospitalBoston, United StatesNo longer taking part
The Cooper Health SystemCamden, United StatesTaking people
Cardiovascular Research Solutions (MyCardiologist)Celebration, United StatesNo longer taking part
Medical University of South CarolinaCharleston, United StatesTaking people
Atrium Health - Sanger HeartCharlotte, United StatesNo longer taking part
University of ChicagoChicago, United StatesTaking people
The Lindner Research CenterCincinnati, United StatesNo longer taking part
Clearwater Cardiovascular ConsultantsClearwater, United StatesNo longer taking part
OhioHealth CorporationColumbus, United StatesNo longer taking part
The Ohio State UniversityColumbus, United StatesNo longer taking part
Citrus Cardiology ConsultantsCrystal River, United StatesNo longer taking part
Baylor Scott & White Research InstituteDallas, United StatesTaking people
South Denver CardiologyDenver, United StatesNo longer taking part
Henry Ford HealthDetroit, United StatesNo longer taking part
Penn Medicine at Doylestown Health CardiologyDoylestown, United StatesNo longer taking part
The Cardiac and Vascular InstituteGainesville, United StatesNo longer taking part
Stern Cardiovascular Foundation, Inc.Germantown, United StatesNo longer taking part
Adventist Health GlendaleGlendale, United StatesTaking people
Colorado Heart and VascularGolden, United StatesNo longer taking part
Intermountain Health Lutheran HospitalGolden, United StatesNo longer taking part
Hackensack University Medical CenterHackensack, United StatesNo longer taking part
Memorial Healthcare SystemHollywood, United StatesNo longer taking part
Baptist Health - JacksonvilleJacksonville, United StatesNo longer taking part
University of Kansas Medical CenterKansas City, United StatesTaking people
Penn Medicine Lancaster General HealthLancaster, United StatesNo longer taking part
UMH-Sparrow Clinical ResearchLansing, United StatesNo longer taking part
Baptist Health LexingtonLexington, United StatesNo longer taking part
UCHealth - Medical Center of the RockiesLoveland, United StatesTaking people
Centra Health dba Stroobants Cardiovascular CenterLynchburg, United StatesNo longer taking part
WellStar Research InstituteMarietta, United StatesNo longer taking part
Virtua Medical Group, P.A.Marlton, United StatesTaking people
Baptist Health South FloridaMiami, United StatesNo longer taking part
Mount Sinai Medical Center of FloridaMiami Beach, United StatesNo longer taking part
Advocate Aurora Research Institute, LLCMilwaukee, United StatesNo longer taking part
Minneapolis Heart InstituteMinneapolis, United StatesTaking people
West Virginia UniversityMorgantown, United StatesNo longer taking part
Ascension St. Thomas HospitalNashville, United StatesNo longer taking part
Jersey Shore University Medical CenterNeptune City, United StatesNo longer taking part
Northwell Health, Inc.New Hyde Park, United StatesNo longer taking part
Ochsner Medical CenterNew Orleans, United StatesNo longer taking part
Icahn School of Medicine at Mount SinaiNew York, United StatesTaking people
Hoag Memorial Hospital PresbyterianNewport Beach, United StatesNo longer taking part
South Oklahoma Heart ResearchOklahoma City, United StatesTaking people
Hightower Clinical TrialsOklahoma City, United StatesNo longer taking part
University of OklahomaOklahoma City, United StatesNo longer taking part
Hospital of the University of PennsylvaniaPhiladelphia, United StatesNo longer taking part
Penn Presbyterian Medical CenterPhiladelphia, United StatesNo longer taking part
WakemedRaleigh, United StatesNo longer taking part
StanfordRedwood City, United StatesNo longer taking part
The Valley HospitalRidgewood, United StatesNo longer taking part
Mayo ClinicRochester, United StatesNo longer taking part
University of Rochester - Cardiology CCTURochester, United StatesNo longer taking part
Scripps ClinicSan Diego, United StatesNo longer taking part
Sutter Valley HospitalsSan Francisco, United StatesTaking people
Sarasota Memorial HospitalSarasota, United StatesNo longer taking part
HonorHealthScottsdale, United StatesNo longer taking part
Washington University St. LouisSt Louis, United StatesNo longer taking part
MedStar Washington Hospital CenterWashington D.C., United StatesNo longer taking part
Cardiovascular Research Institute of KansasWichita, United StatesTaking people
West Houston Area Clinical Trial Consultants (Wichita, KS)Wichita, United StatesNo longer taking part
Michigan HeartYpsilanti, United StatesNo longer taking part

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: Orchestra BioMed, Inc
Trial code: NCT06059638
Record updated: 2 October 2026
Original description: A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.Read full original descriptionShow less
A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.
Inclusion: Patient has or is indicated for a dual-chamber pacemaker. Visit 1 can be performed within 30 days prior to a planned implant of a Medtronic Astra/Azure dual-chamber pacemaker system or at any time thereafter; On a stable antihypertension treatment regimen with at least 1 class of antihypertensive drug; Office SBP ≥135 mmHg and <180 mmHg; Average 24-Hour aSBP ≥130 mmHg and <170 mmHg.
Exclusion: Prior percutaneous or surgical coronary, carotid, or endovascular intervention within 3 months; Has an active or prior device-based anti-hypertensive treatment (e.g., renal denervation procedure, baroreflex activation therapy); History of cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 6 months; Myocardial infarction (MI) within 3 months; Has an existing active cardiac device or neurostimulator other than the recent Astra/Azure pacemaker implant; LVEF <50%; NYHA Class III-IV; Permanent atrial fibrillation; Mitral valve regurgitation greater than or equal to grade 3; Aortic stenosis with a valve area less than 1.5 cm2.
ClinicalTrials.gov NCT06059638