Ultrasound and breathing signals to study lung diseases
Compares lung ultrasound and breathing signals in adults with interstitial lung disease or COPD.
Plain-language title generated from the registry record
Registry title: Ultrasound and Respiratory Physiological Signals in Lung Diseases
Key facts
- Where
- Rome, ItalySee the site
Where in Italy
- Fondazione Policlinico Universitario A. Gemelli IRCCSRome, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Trial code
- NCT06068647
- Record updated
- 20 May 2026
- Original description
The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted.Read full original descriptionShow less
Synergistic Assessment of Ultrasound Data and Respiratory physiOlogical Signals in luNg Diseases
The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted.
However, the use of ultrasound to explore the state of the peripheral lung parenchyma, when the organ is still aerated, is a relatively new application.
Horizontal and vertical artifacts are separate and distinct artifacts that can be seen during ultrasound examination of the lungs. While the practical role of lung ultrasound artifacts is accepted to detect and monitor many conditions, further research is needed for the physical interpretation of ultrasound artifacts. These artifacts are diagnostic signs, but we don't fully understand their origin.
The artifactual information deriving from the surface acoustic interaction, beyond the pleural line, in the ultrasound images of the normally aerated and non-deflated lung, represents the final result of complex interactions of acoustic waves with a specific three-dimensional structure of the biological tissue. Thus, the umbrella term "vertical artifacts" oversimplifies many physical phenomena associated with a pathological pleural plane. There is growing evidence that vertical artifacts are caused by physiological and pathological changes in the superficial lung parenchyma.
Therefore, the need emerges to explore the physical phenomena underlying the artifactual ultrasound information deriving from the surface acoustic interaction of ultrasound with the pleuro-pulmonary structures.
Inclusion: inpatients admitted to the hospital due to diffuse interstitial lung diseases during exacerbation OR infectious interstitial pneumonia not caused by SARS-CoV-2 OR acute exacerbation of chronic obstructive pulmonary disease; Outpatients with pulmonary paraseptal and/or panlobular emphysema and/or chronic obstructive pulmonary disease during stable phase; Patients able to give written informed consent.
Exclusion: Presence of electromagnetic disturbances or significant ionizing radiation sources which might lead to signal artifacts; history of skin irritation, redness, itching or allergic cutaneous symptoms; Allergic reactions to adhesives or hydrogels; Family history of adhesive skin allergies; Presence of severe skin conditions such as wounds, burns or on any damaged skin; Use of external cardiac defibrillators; Use of extra cardiac stimulators; Presence of strong magnetic fields in the study setting; Use of diaphragmatic pacers; Pregnancy; Pediatric population.