Frontlight ResearchEarly access
TerminatedNo phase
The Longitudinal Study of Stimulant Use Disorder
Key facts
- Who runs it
- University of Texas Southwestern Medical Center
- Where
- Dallas, United StatesSee the site
- Trial code
- Status
- Terminated
- People taking part
- 72 people enrolled
- Started
- 16 Nov 2023
- Ended
- 31 Mar 2025
- Type of study
- Observational
- Record updated
- 8 April 2025
- Why it stopped
- Funding
Who can take part
- Age
- 18 years to 85 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Be an adult between the ages of 18-85, inclusive
- Be able to sufficiently understand, speak, and read English to provide informed consent and ask relevant questions
- For participants with current/history of Stimulant Use Disorder: Subjects must meet MINI International Neuropsychiatric Inventory (MINI) criteria for current stimulant use disorder or meet MINI supplemental criterial for lifetime stimulant use disorder. For Healthy control individuals: Subjects must meet criteria for a healthy control: No history of substance use disorder or other mental illness as defined by the MINI International Neuropsychiatric Inventory (MINI)
- Be willing to provide consent and comply with all procedure instructions
- Be willing to provide blood samples and participate in EEGs and MRIs
Who cannot take part
- For participants with stimulus use disorder cohort: Have a history of schizophrenia, schizoaffective disorders, or chronic psychotic disorders based on the MINI. For healthy control individuals: Have a history of substance use disorder or any other psychiatric disorder as defined by the MINI and supplemental questions
- Have any condition for which study participation would not be in their best interest (e.g., cognitive impairment, unstable general medical condition, intoxication, active psychosis) or that could prevent, limit, or confound the protocol-specified assessments, in the opinion of the investigator or their designee
- Require immediate hospitalization for psychiatric disorder or suicidal risk as assessed by a licensed study clinician
Where in United States
- UT Southwestern Medical CenterDallas, United States
About the trial
What the trial wants to find out
This research is a 5-year observational, longitudinal registry study with no treatment or medication provided as part of participation. Individuals with current or lifetime stimulant use disorder, in addition to healthy control individuals, may be eligible to participate in this study. A variety of assessments and tasks including Magnetic Resonance Imaging (MRI), Electroencephalography (EEG), blood draws, urine drug screens, and both self-report and clinician-rated assessments will be used to assess biomarkers in this population. This study has a visit schedule of four in-person visits and eight remote visits per year.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Observational Longitudinal Study of Individuals With Stimulant Use Disorder: Research and Development of a Biosignature
- Record updated
- 8 April 2025