Cognitive Training for Veterans with Lasting Thinking Problems After COVID-19
Compares two thinking-skills training programs in Veterans with lasting thinking problems after COVID-19.
Plain-language title generated from the registry record
Registry title: Cognitive Rehabilitation Therapy for COVID-19
Key facts
- Where
- San Diego, United StatesSee the site
Where in United States
- VA San Diego Healthcare System, San Diego, CASan Diego, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT06086379
- Record updated
- 15 July 2026
- Original description
Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans' community functioning and quality of life, contribute to significant human suffering, and are costly to VHA. Rehabilitation is a critical priority for Veterans with long COVID. One promising treatment to improve functioning in Veterans with post-COVID-19 cognitive symptoms is Compensatory Cognitive Training (CCT). Previous studies have found that CCT is feasible, acceptable, and efficacious in Veteran populations with multiple sources of cognitive dysfunction. This randomized controlled trial aims to address important RR\&D priorities by examining feasibility, acceptability, and preliminary efficacy of a COVID-19-specific rehabilitation intervention, CCT for long COVID (CCT-C) compared to a robust control condition. The proposed study has the potential to improve cognitive function, functional independence, and quality of life for Veterans with late or delayed effects of secondary conditions related to COVID-19 infections.Read full original descriptionShow less
Cognitive Rehabilitation to Improve Functioning in Veterans Following COVID-19
Cognitive dysfunction, psychiatric symptoms, functional impairment, and disability following COVID-19 negatively impact Veterans' community functioning and quality of life, contribute to significant human suffering, and are costly to VHA. Rehabilitation is a critical priority for Veterans with long COVID. One promising treatment to improve functioning in Veterans with post-COVID-19 cognitive symptoms is Compensatory Cognitive Training (CCT). Previous studies have found that CCT is feasible, acceptable, and efficacious in Veteran populations with multiple sources of cognitive dysfunction. This randomized controlled trial aims to address important RR\&D priorities by examining feasibility, acceptability, and preliminary efficacy of a COVID-19-specific rehabilitation intervention, CCT for long COVID (CCT-C) compared to a robust control condition. The proposed study has the potential to improve cognitive function, functional independence, and quality of life for Veterans with late or delayed effects of secondary conditions related to COVID-19 infections.
Inclusion: Veterans > 18 years old who are able to provide informed consent; Prior participation in SF Parent Study or LA Parent Study; Report of cognitive symptoms that Veteran attributes to COVID-19 infection.
Exclusion: Current substance abuse disorder, psychotic disorder, dementia, etc; History of moderate to severe brain injury with loss of consciousness > 30 minutes; Auditory or visual impairments that would prevent the ability to participate in assessment procedures; Invalid performance on one or more embedded performance validity tests (PVTs).