Brain MRI study of salt sensing in people with salt-sensitive high blood pressure
Tests how the brain responds to a salt infusion in adults with salt-sensitive blood pressure.
Plain-language title generated from the registry record
Registry title: Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
Key facts
- Where
- Newark, United StatesSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 60 years old?
Source: NCT06094816, who can take part
Where in United States
- University of DelawareNewark, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Delaware
- Trial code
- NCT06094816
- Record updated
- 24 March 2026
- Original description
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.Read full original descriptionShow less
Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study
The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.
Inclusion: Age: > 40 years or < 60 years; Blood pressure: > 100/60 mmHg or < 140/90 mmHg; BMI: > 18.5 kg/m2 or < 35 kg/m2; Serum potassium: > 3.5 mmol/L or < 5.5 mmol/L; No history of cardiovascular, renal, metabolic, or neurological disease.
Exclusion: Hormone replacement therapy; Contra-indications to MRI (implants, metal, etc); History of - cardiovascular, cancer, metabolic, respiratory, renal disease; Clinically diagnosed psychiatric or neurological disorder; Psychiatric, neurological, anxiety or depression medications; Hypertension medications; Sulfonamide drug allergy; Serum potassium: < 3.5 mmol/L or > 5.5 mmol/L; Major brain injury (concussions do not count); Age: < 40 years or > 60 years; Blood pressure: < 100/60 mmHg or > 140/90 mmHg; BMI: < 18.5 kg/m2 or > 30 kg/m2; Abnormal ECG; Current tobacco or nicotine use; Pregnant or nursing mothers; Clinically diagnosed anxiety or depression; Claustrophobia.