Testing fast-ripple brain signals to guide epilepsy surgery planning
Tests special electrodes and fast-ripple brain signals in adults with hard-to-treat epilepsy.
Plain-language title generated from the registry record
Registry title: Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
Key facts
- Where
- Amiens, Bordeaux, La Tronche, Le Kremlin-Bicêtre, Lille, Lyon, Nancy, Paris, Rennes, Strasbourg, and Toulouse, FranceSee the 12 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06105645, who can take part
Where in France
- Chu Amiens PicardieAmiens, FranceTaking people
- University Hospital of BordeauxBordeaux, FranceTaking people
- University hospital of Grenoble-AlpesLa Tronche, FranceTaking people
- APHP Hôpital BicêtreLe Kremlin-Bicêtre, FranceTaking people
- CHU de LilleLille, FranceTaking people
- Hospices Civils de LyonLyon, FranceTaking people
- CHRU de NancyNancy, FranceTaking people
- Fondation Adolphe de RothschildParis, FranceTaking people
- Hopital Pitie-SalpetriereParis, FranceTaking people
- CHU de RennesRennes, FranceTaking people
- Hopitaux Universitaires de StrasbourgStrasbourg, FranceTaking people
- University Hospital of ToulouseToulouse, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Toulouse
- Trial code
- NCT06105645
- Record updated
- 21 October 2026
- Original description
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as measured by freedom from disabling seizures one-year post-surgery.Read full original descriptionShow less
Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as measured by freedom from disabling seizures one-year post-surgery.
220 patients (for whom 4-6 usual clinical macro-electrodes will be replaced by hybrid micro-macro electrodes and for whom fast-ripples will be assessed) distributed over 6 centres and 220 control patients(who will undergo an SEEG with the usual electrodes and for whom fast-ripples will not be assessed) distributed over 6 centres. This is a controlled, non-randomized, parallel plan, prospective, multicentre exploratory study.
Inclusion: Patient suffering from drug-resistant focal epilepsy (DRFE), as defined by the International League Against Epilepsy, undergoing SEEG, the indication of which was selected during a multidisciplinary epilepsy meeting; Patient who has given written informed consent to allow the study data collection procedures; Patient covered by the French healthcare system.
Exclusion: Patient with a cardiac defibrillator; Patients under juridical protection (authorship, curators or safeguarding of justice); Patient deprived of liberty by a judicial or administrative decision; Patient in exclusion period of another study; No other non-inclusion criteria since the study will only be proposed to patients who already meet the criteria for a SEEG.